Irsogladine maleate
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- CAS-Nr.
- 84504-69-8
- Englisch Name:
- Irsogladine maleate
- Synonyma:
- Irgas;gaslon;mn-1695;Inomarl;Gasroil;Gaslon N;Irsogladin maleate;Irsogladine maleate;Maleate irsogladine;IrsogladineMaleate>
- CBNumber:
- CB8105343
- Summenformel:
- C13H11Cl2N5O4
- Molgewicht:
- 372.16
- MOL-Datei:
- 84504-69-8.mol
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Irsogladine maleate Eigenschaften
- Schmelzpunkt:
- 181-182°C
- storage temp.
- Inert atmosphere,Room Temperature
- Wasserl?slichkeit
- Insoluble in water
- L?slichkeit
- DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM)
- Aggregatzustand
- White crystalline powder.
- Farbe
- White to Almost white
- Merck
- 14,5102
- InChI
- InChI=1S/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-
- InChIKey
- PJLVTVAIERNDEQ-BTJKTKAUSA-N
- SMILES
- N1=C(C2=CC(Cl)=CC=C2Cl)N=C(N)N=C1N.C(O)(=O)/C=C\C(O)=O
- CAS Datenbank
- 84504-69-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RTECS-Nr. |
XY5930000 |
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| HS Code |
2933.69.6050 |
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| Toxizit?t |
LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P281 |
Vorgeschriebene pers?nliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Irsogladine maleate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemische Eigenschaften
White Solid
Biologische Aktivit?t
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Irsogladine maleate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Irsogladine maleate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 262)Lieferanten
84504-69-8()Verwandte Suche:
Dinatriumfumarat
6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
1-(2-Oxo-2-pyrrolidin-1-ylethyl)-4-[3-(3,4,5-trimethoxyphenyl)acryloyl]piperazinmonomaleat
1,3,5-Triazin
gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1)
Maleins?ure
3,4'-DIAMINODIPHENYLMETHANE
Irsogladine
Dichlor(methyl)(phenyl)silan
Dichlor(diphenyl)silan
Fumarsure
(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat
Maleins?ureanhydrid
Chlorbenzol
- 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinemaleate
- 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinmaleate
- 3,5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-(z)-2-butenedioate(1:1)
- gaslon
- mn-1695
- 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate
- Irsogladin maleate
- Gaslon N
- Gasroil
- Inomarl
- Irgas
- Irsogladine maleate
- 1,3,5-Triazine-2,4-diaMine,6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)
- Maleate irsogladine
- 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diaMine (2Z)-2-Butenedioate
- IrsogladineMaleate>
- Irsogladine maleate USP/EP/BP
- 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate(1:1)
- Irsogladine MaleateQ: What is
Irsogladine Maleate Q: What is the CAS Number of
Irsogladine Maleate Q: What is the storage condition of
Irsogladine Maleate Q: What are the applications of
Irsogladine Maleate
- Irsogladine Maleate, ≥ 98.0%
- Irsogladine maleate - Bio-X ?
- 84504-69-8
- 4504-69-8
- C9H7Cl2N5C4H4O4
- C13H11Cl2N5O4
- C9H7Cl2N5C4H4O4C13H11Cl2N5O4
- C9H7Cl2N5C4H4O4C
- Amines
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
