Tolciclat Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Tolmicen,Carlo Erba,Italy,1979

Manufacturing Process

Thiophosgene (1.15 g, 0.01 mol) in chloroform (40 ml) was slowly treated at room temperature with sodium 1,4-methano-1,2,3,4-tetrahydro-6- naphthoxide (1.82 g, 0.01 mol). After 30 minutes, N-methyl-m-toluidine (2.42 g, 0.02 mol) in chloroform (40 ml) was added dropwise to the solution so obtained at room temperature. The reaction mixture was stirred for 48 hours at room temperature and then refluxed for 2 hours. The solvent was evaporated, and the residue redissolved in water and extracted repeatedly with diethyl ether. The organic phase was dried (Na2SO4) and evaporated to dryness to give, after crystallization from isopropanol, O-(1,4-methano- 1,2,3,4-tetrahydro-6-naphthyl)-N-methyl-N-(m-tolyl)-thiocarbamate (1.3 g) melting point 92°C to 94°C.

Therapeutic Function

Topical antimycotic

Antimicrobial activity

In vitro, tolciclate has a narrow activity spectrum with good efficacy only towards dermatophytes. Isolates of susceptible species showing primary resistance or developing secondary resistance are rarely observed.

Tolciclat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Tolciclat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32281	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19903	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	20622	58

50838-36-3(Tolciclat)Verwandte Suche:

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• 1,4-Methanonaphthalene, carbamothioic acid deriv.
• Carbamothioic acid, methyl(3-methylphenyl)-, O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester (9CI)
• Fungifos
• K 9147
• KC 9147
• Kilmicen
• Tolmicen
• N-(3-Methylphenyl)-N-methylthiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
• N-(3-Methylphenyl)-N-methylthiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalenanonaphthalen-6-yl)
• N-Methyl-N-(m-tolyl)thiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
• Aids029681
• Aids-029681
• Carbamothioic acid, methyl(3-methylphenyl)-, o-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
• Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
• 50838-36-3