Adaptaquin Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This brain-penetrant PHD2 inhibitor and antioxidant (FW = 377.82 g/mol; CAS 385786-48-1; Soluble to 100 mM in DMSO), also named 7-[(4chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol, targets Hypoxia-Inducible Factor (or HIF) prolyl hydroxylase-2, a critical regulator of hematopoietic stem cell (HSC) maintenance during steadystate and stress. Indeed, this branched oxyquinoline molecule was named adaptaquin (AQ) to signify its ability to inhibit the HIF-PHDs and activate adaptive responses to hypoxia. Hypoxia is a prominent feature in the maintenance of HSC quiescence and multipotency. Adaptaquin also exhibits neuroprotective effects, enhancing functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes.

Adaptaquin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Adaptaquin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32375	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238	sales@sun-shinechem.com	China	1048	64
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	12952	65
Shanghai Haozhixiang Biotechnology Co., Ltd	526763801 13301653310	526763801@qq.com	China	8434	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9803	58
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	71826	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	6688	55
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58

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• Adaptaquin
• HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem
• 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
• Hypoxia-inducible factors,peroxidation,mitochondrial,HIFs,HIF-PH,inhibit,HIF-PHD2,HIF/HIF Prolyl-Hydroxylase,Adaptaquin,Inhibitor
• 8-Quinolinol, 7-[(4-chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-
• 7-((4-Chlorophenyl)((3-hydroxypyridin-2-yl)amino)methyl)quinolin-8-ol
• Adaptaquin, 10 mM in DMSO
• 385786-48-1