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Lotilaner

Lotilaner Struktur
1369852-71-0
CAS-Nr.
1369852-71-0
Englisch Name:
Lotilaner
Synonyma:
Lotilaner;Lothilana;Lotilaner (TP-05);Lotilaner Impurity2;Lotilaner, 10 mM in DMSO;Parasite,Inhibitor,γ-Aminobutyric acid Receptor,Lotilaner,inhibit,Gamma-aminobutyric acid Receptor,GABA Receptor;(S)-3-Methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)a mino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluo romethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2- carboxamide;2-Thiophenecarboxamide, 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-;(S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide
CBNumber:
CB73344768
Summenformel:
C20H14Cl3F6N3O3S
Molgewicht:
596.76
MOL-Datei:
1369852-71-0.mol

Lotilaner Eigenschaften

Dichte
1.66±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO : ≥ 100 mg/mL (167.57 mM)
Aggregatzustand
Solid
pka
12.52±0.46(Predicted)
Farbe
White to off-white
InChIKey
HDKWFBCPLKNOCK-SFHVURJKSA-N
SMILES
C1(C(NCC(=O)NCC(F)(F)F)=O)SC(C2C[C@](C3=CC(Cl)=C(Cl)C(Cl)=C3)(C(F)(F)F)ON=2)=CC=1C

Sicherheit

Lotilaner Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Lotilaner is a representative of the isoxazolines, a new class of insecticides discovered in the 2000s.
Isoxazolines (Afoxolaner, Fluralaner, Lotilaner, and Sarolaner) Isoxazolines are insecticidal and arachnicidal substances that can be given orally, or topically as spot-ons, and act systemically in the blood circulation.
lotilaner (Credeliot), a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp.
Lotilaner, like the other isooxazolines is active against fleas, mites, and ticks. After oral administration or topical application, it can kill fleas rapidly.

Verwenden

Lotilaner is a new member of the isoxazoline class for the treatment of flea and tick infestations in cats.

Indications

Lotilaner is a monthly chewable tablet for the treatment and prevention of fleas and ticks. It is used in dogs and puppies 8 weeks of age or older weighing 4.4 pounds or greater (Elanco, 2019).

Nebenwirkungen

These include weight loss, elevated blood urea nitrogen, increased urination, and diarrhea (Elanco, 2019).

Lotilaner Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2-Thiophenecarboxylic acid, 5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl- Isoxazole, 3-(5-bromo-4-methyl-2-thienyl)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)- 5-BROMO-3-METHYLTHIOPHENE-2-CARBOXYLIC ACID 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride

Downstream Produkte

Lotilaner Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 106)Lieferanten
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  • Lotilaner
  • (S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide
  • 2-Thiophenecarboxamide, 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
  • Parasite,Inhibitor,γ-Aminobutyric acid Receptor,Lotilaner,inhibit,Gamma-aminobutyric acid Receptor,GABA Receptor
  • (S)-3-Methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)a mino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluo romethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2- carboxamide
  • Lotilaner (TP-05)
  • Lotilaner, 10 mM in DMSO
  • Lotilaner Impurity2
  • Lothilana
  • 1369852-71-0
  • C20H14Cl3F6N3O3S
  • 1
  • API
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