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2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Struktur
1030825-20-7
CAS-Nr.
1030825-20-7
Englisch Name:
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
Synonyma:
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene;)-5-(4-fL;Canogliflozin;Canagliflozin-19;CanagliflozinINT;Canagliflozin INT4;2-(5-Bromo-2-methyL;CAGLIFLOZIN IMPURITY C;Canagliflozin Bromo Imp;Kagliflozin impurity 24
CBNumber:
CB72603549
Summenformel:
C18H14BrFS
Molgewicht:
361.27
MOL-Datei:
1030825-20-7.mol

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Eigenschaften

Schmelzpunkt:
103 °C
Siedepunkt:
438.3±40.0 °C(Predicted)
Dichte
1.388
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
L?slichkeit
DMSO (Slightly, Heated), Hexanes (Slightly, Heated)
Aggregatzustand
Solid
Farbe
White to Off-White
InChI
InChI=1S/C18H14BrFS/c1-12-2-5-15(19)10-14(12)11-17-8-9-18(21-17)13-3-6-16(20)7-4-13/h2-10H,11H2,1H3
InChIKey
VLRIERSBZHUCOW-UHFFFAOYSA-N
SMILES
C1(CC2=CC(Br)=CC=C2C)SC(C2=CC=C(F)C=C2)=CC=1
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2934999090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P321 Besondere Behandlung
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P362 Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Chemische Eigenschaften,Einsatz,Produktion Methoden

Synthese

prepares 2-(4-fluorophenyl) thiophene III:
Prepared by Grignard reagent: N 2under protection; magnesium chips (11.7g is added in the 500mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed; 480mmol), THF (15.0mL), drips 2 p-Fluoro bromo benzenes; add the initiation reaction of 2 iodine post-heating; p-Fluoro bromo benzene (70.0g, 400mmol) is dissolved in THF (250mL), after under reflux, drip the THF solution of p-Fluoro bromo benzene; drip Bi Baowen backflow 2h, GC detection feedstock conversion complete.
synthesis of 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
Linked reaction: N 2under protection; in the 1000mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed, add 2-bromothiophene (52.2g, 320mmol), under stirring, add two (methyl ethyl diketone) palladium (23.4mg; 0.0320mmol); THF (200mL), is heated to 50 DEG C, the above-mentioned Grignard reagent prepared of rear dropping; drip to finish and be warming up to 60 DEG C; insulation 1h, GC detect to raw material reaction complete, terminate reaction.System is cooled to 30 DEG C, drips dilute hydrochloric acid (2M, 150mL) under ice-water bath, drips complete vigorous stirring 0.5h, removes ice-water bath and make system naturally rise to room temperature, stratification, water layer CH 2cl 2(100mL × 3) extract, merge organic phase saturated sodium-chloride 200mL to wash, rear drying, concentrating under reduced pressure obtain light tan solid, vacuum-drying to constant weight obtains 2-(4-fluorophenyl) thiophene III (57.4g, 312mmol), it is 98.5% that GC detects purity, and yield is 99.1%.
1H NMR(500MHz,CDCl 3)δ7.65～7.54(m,2H),7.33～7.22(m,2H),7.14～7.03(m,3H).Gc-Ms:178.1.

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2-(4-Fluorophenyl)-thiophene (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone 4-bromo-2-(chloromethyl)-1-methylbenzene Tetrahydrofuran BORANE THF

Downstream Produkte

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 404)Lieferanten
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ivan@atkchemical.com China 33024 60

1030825-20-7()Verwandte Suche:

  • 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
  • Thiophene, 2-[(5-broMo-2-Methylphenyl)Methyl]-5-(4-fluorophenyl)-
  • Canagliflozin Intermediate2
  • Canagliflozin INT4
  • Canogliflozin
  • Canagliflozin Intermediate II
  • 2-(5-bromo-2-methyl-benzyl-(5-fluorophenyl)thiophene
  • 2-(4-fluorophenyl)-5-[(5-bromo-2-methylphenyl)methyl]thiophene
  • 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 98%
  • Canagliflozin Impurity 52
  • Canagliflozin-19
  • 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
  • 1030825-20-7 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
  • Canagliflozin Bromo Imp
  • )-5-(4-fL
  • 2-(5-Bromo-2-methyL
  • Canagliflozin Bromo Impurity
  • 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl]thiophene (Canagliflozin Impurity)
  • 2-((5-bromo-2-methylphenyl)methyl)-5-(4-fluorophenyl)thiophe...
  • canagliflozin impurities603
  • canagliflozin impurities1
  • Canagliflozin impurity CQ: What is Canagliflozin impurity C Q: What is the CAS Number of Canagliflozin impurity C Q: What is the storage condition of Canagliflozin impurity C
  • 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
  • 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thio
  • CanagliflozinINT
  • CAGLIFLOZIN IMPURITY C
  • 2- (2-methyl-5-bromobenzyl) -5- (4-fluorobenzene) thiophene
  • 2-(5-Bromo-2- Methylbenzyl)-5-(4-fIuorophenyl) t
  • Kagliflozin impurity 24
  • 2-(2-Methyl-5-bromobenzyl)-5-(4-fluorophenyl)thiophene
  • 1030825-20-7
  • C18H14BrFS
  • Pharmaceutical intermediates
  • 1030825-20-7
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