Tobramycin
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Tobramycin Eigenschaften
- Schmelzpunkt:
- 178 °C
- alpha
- D20 +129° (c = 1 in water)
- Siedepunkt:
- 570.01°C (rough estimate)
- Dichte
- 1.3458 (rough estimate)
- Brechungsindex
- 143 ° (C=4, H2O)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- H2O: 50 mg/mL, clear, faintly yellow
- pka
- pKa 6.7 (Uncertain);8.3 (Uncertain);9.9 (Uncertain)
- Aggregatzustand
- White to off-white solid
- Farbe
- white to off-white
- Wasserl?slichkeit
- Soluble in water
- Merck
- 14,9490
- BRN
- 1357507
- Stabilit?t:
- Hygroscopic
- InChIKey
- NLVFBUXFDBBNBW-TYINOFMDNA-N
Sicherheit
Kennzeichnung gef?hrlicher | Xi | ||
---|---|---|---|
R-S?tze: | 36/37/38 | ||
S-S?tze: | 26-37/39 | ||
WGK Germany | 2 | ||
RTECS-Nr. | WK2100000 | ||
F | 3-10 | ||
HS Code | 29419090 | ||
Giftige Stoffe Daten | 32986-56-4(Hazardous Substances Data) | ||
Toxizit?t | LD50 in mice, rats (mg/kg): 441, 969 s.c. (Welles) |
Tobramycin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Tobramycin is one component (factor 6) of a mixture produced by fermentation of Streptomyces tenebrari us. Lacking the C-3′ hydroxyl group, it is not a substrate for APH(3′)-1 and APH(3′)-II and so has an intrinsically broader spectrum than kanamycin. It is a substrate, however, for adenylation at C-2′ by ANT (2′) and acetylation at C-3 by AAC(3)-I and AAC(3)-II and at C-2′ by AAC(2′).Chemische Eigenschaften
White or almost white powder.Verwenden
Tobramycin is an aminoglycoside antibiotic.Definition
ChEBI: A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.Indications
Tobramycin is highly active with respect to Gram-negative microorganisms (blue-pus bacillus and gastric bacilli, rabbit fever, serratia, providencia, enterobacteria, proteus, salmonella, shigella), as well as Gram-positive microorganisms (staphylococci, including those resistant to penicillin and some cephalosporins), and a few strains of streptococci.It is used for severe bacterial infections: peritonitis, sepsis, meningitis, osteomyelitis, endocarditis, pneumonia, pleural empyema, pulmonary abscess, purulent skin infections and soft tissue infections, and infections of the urinary tract caused by microorganisms that are sensitive to the drug. Synonyms of this drug are nebicine, obracine, and others.
Antimicrobial activity
In-vitro activity against Ps. aeruginosa is usually somewhat greater than that of gentamicin; against other organisms activity is similar or a little lower. Other Pseudomonas species are generally resistant, as are streptococci and most anaerobic bacteria. Other organisms usually susceptible in vitro include Acinetobacter, Legionella and Yersinia spp. Alkaligenes, Flavobacterium spp. and Mycobacterium spp. are resistant. It exhibits bactericidal activity at concentrations close to the MIC and bactericidal synergy typical of aminoglycosides in combination with penicillins or cephalosporins.Acquired resistance
It is inactivated by many aminoglycoside-modifying enzymes that inactivate gentamicin. However, AAC(3′)-I does not confer tobramycin resistance and AAC(3′)-II confers a lower degree of tobramycin resistance than of gentamicin resistance. Conversely, ANT(4′) confers tobramycin but not gentamicin resistance, as do some types of AAC(6′). Overproduction of APH(3′), conferring a low degree of resistance to tobramycin (MIC 8 mg/L), but not gentamicin (MIC 2 mg/L), was ascribed to ‘trapping’ rather than phosphorylation.Resistance rates are generally similar to those of gentamicin, although they may vary locally because of the prevalence of particular enzyme types.
Biologische Aktivit?t
Pharmacologically, tobramycin is quite similar to gentamicin. The drug is somewhat more active against Ps. aeruginosa than gentamicin. Tobramycin also acts synergistically with penicillin, but to a lesser degree than gentamicin.Clinical Use
Severe infections caused by susceptible micro-organisms Ps. aeruginosa infections, including chronic pulmonary infections in cystic fibrosis (administration by injection or nebulizer)For practical purposes use is identical to that of gentamicin, except possibly for Pseudomonas infection, where it has somewhat greater activity against gentamicin-susceptible and some gentamicin-resistant strains. Its value as a substitute for gentamicin in the speculative treatment of severe undiagnosed infection is offset by its lower activity against other organisms that may be implicated.
It has been used extensively to treat Ps. aeruginosa infections in patients with cystic fibrosis.
Tobramycin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Ammoniak, wssrige Lsung
Glucose
Ethanol
Ammoniumchlorid
Hydrogenchlorid
Strke
Magnesiumsulfat
Magnesium sulfate heptahydrate
Hefe, Extrakt
Triphenylphosphin
POLYPEPTONE
Wasserstoff
Bekanamycin
Trimethylsilyl-N-trimethylsilyl-acetamidat
Glycerol
Chlortrimethylsilan
Magnesiumdi(acetat)
MEAT EXTRACT
Aluminium-nickel
Adenosin-5'-triphosphat
Downstream Produkte
Tobramycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 457)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 |
abby@chuanghaibio.com | China | 8773 | 58 |
Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 |
sales@hbmojin.com | China | 12644 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; |
info@fortunachem.com | China | 5949 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-17396673057 |
linda@tnjone.com | China | 1143 | 58 |
Apeloa production Co.,Limited | +8619933239880 |
admin@apcl.com.cn | China | 861 | 58 |
Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 |
Jerry@xhobio.com | China | 884 | 58 |
Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 |
niki@zlchemi.com | China | 7245 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21622 | 55 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19552 | 58 |
32986-56-4(Tobramycin)Verwandte Suche:
Trometamol
Azithromycin
ALTRENOGEST
Centchroman
Glycin
Doxycyclin
(1,2-Phenylenbis(iminocarbono-thioyl))bis-carbamin-s?ure-diethylester
3-Aminophenol
Aminocapronsure
Tetrahydropyran
Gentamicin
Clindamycin
Vancomycin
Bekanamycin
Tobramycin sulfate
Tobramycinsulfat
Dibekacin
Tobramycin
- Tobramycin (350 mg)
- Tobramycin (350 mg)L0E077970ug/mg(an)
- TobraMycin Base API
- Tobramycin, Antibiotic for Culture Media Use Only
- TOBRAMYCIN (RE-EXPORT OF REJECTED MATERIAL RETURN TO VENDOR)
- 1-epitobramycin
- 3’-deoxykanamycinb
- 4-[2,6-diamino-2,3,6-trideoxy-alpha-d-glycopyranosyl]-6-[3-amino-3-deoxy-alpha
- 6-trideoxy-alpha-d-ribo-hexopyranosyl-(1-4))-2-deoxy-
- d-6-trideoxy-alpha-d-ribohexopyranosyl-(1-6))-2-deoxy
- d-6-tyrideoxy-alpha-d-ribohexopyranosyl-(1-6))-2-deoxy
- O-[3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL-(1->6)]-O-[2,6-DIAMINO-2,3,6-TRIDEOXY-ALPHA-D-RIBOHEXOPYRANOSYL-(1->4)]-2-DEOXY-D-STREPTAMINE
- Tobramycin, Free Base
- TobramycinSulphate49842-07-1/Base
- O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-
- O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1-6)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(1-4)]-2-deoxy-D-streptamine
- >D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1?6)-O-2,6-diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexopyranosyl-(1?4)-2-deoxy-
- o-[3-amino-3-deoxy-α-d-glucopyranosyl-(1→6)]-o-[2,6-diamino-2,3,6-trideoxy-α-d-ribohexopyranosyl-(1→4)]-2-deoxy-d-streptamine
- D-Streptamine, O-3-amino-3-deoxy-a-D-glucopyranosyl-(16)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(14)]-2-deoxy- (9CI)
- NSC 180514
- O-3-Amino-3-deoxy-a-D-glucopyranosyl-(14)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(16)]-2-deoxystreptamine
- Streptamine, O-3-amino-3-deoxy-a-D-glucopyranosyl-(14)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(16)]-2-deoxy-, D- (8CI)
- Tobracin
- Tobramaxin
- Tobramycetin
- Tobramycin (base and/or unspecified salts)
- O-[3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
- O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1-6)-O-[2,6-diamino-2,3,6-trideoxy-a -D-ribo-hexopyranosyl-(1-4)]-2-deoxy-D-streptamine
- deoxykanamycinb
- -d-glycopyranosyl]-2-deoxystreptamine
- distobram
- gernebcin
- lpha-d-ribohexopyranosyl-(1-4)]-2-deoxy-d-streptamine
- nebicina
- nebramycin6
- nebramycinfactor6
- nebramycinvi
- nf6
- o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-6)-o-[2,6-diamino-2,3,6-trideoxy-a
- obracin
- obramycin
- streptamine,o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(2,6-diamino-2,3,
- tobradistin
- tobralex
- (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxy-oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
- O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1[R]6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1[R]4)]-2-deoxy-D-streptamine
- O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine
- TOBRAMYCIN
- Tobramycin,O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
- Tobramycin, Free Base - CAS 32986-56-4 - Calbiochem
- Tobramycin, potency: ≥900μG/mg,98%
- Tobramycin CRS
- Tobramycin for identification CRS
- D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-
- (2S,3R,4S,5S,6R)-4-amino-2-(((1S,2S,3R,4S,6R)-4,6-diamino-3-(((2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxytetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol
- Tobramycin solution in Water, 100μg/mL
- Tobramycin-[13C6] pentaacetate salt
- O-[3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1->