RP 001 (hydrochloride) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P₁) agonist (EC₅₀ = 9 pM). It is competitive with W146 , a selective S1P₁ antagonist, and induces internalization and polyubiquitination of S1P₁ in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC₅₀ = 0.03 mg/kg). It reduces S1P₁-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1^eGFP/eGFP mice but has no effect in vivo. RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis.

Verwenden

RP 001 Hydrochloride is a picomolar, short-acting S1P1 agonist.

RP 001 (hydrochloride) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

RP 001 (hydrochloride) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32375	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38832	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	1666	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9803	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	26014	58
R&D Systems, Inc	18003437475	rdname@qq.com	China	6960	58
Cayman Chemical Company	800-364-9897	sales@caymanchem.com	China	6838	58
Biosynth Biological Technology (Suzhou) Co Ltd	51288865780	sales@biosynth.com	China	6051	58

---

• RP001 hydrochloride,RP 001 hydrochloride
• N-[4-[5-[3-cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine,monohydrochloride
• 1781880-34-9