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SJA6017

SJA6017 Struktur
190274-53-4
CAS-Nr.
190274-53-4
Englisch Name:
SJA6017
Synonyma:
SJA6017;Calpain-In-4;Calpain Inhibitor 4;CALPAIN INHIBITOR VI;4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL;4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE;N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL;SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal;Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde;Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-
CBNumber:
CB6427018
Summenformel:
C17H25FN2O4S
Molgewicht:
372.45
MOL-Datei:
190274-53-4.mol

SJA6017 Eigenschaften

Dichte
1.185±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO: 5 mg/ml
Aggregatzustand
A lyophilized solid
pka
9.04±0.50(Predicted)
Farbe
white

Sicherheit

SJA6017 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases μ-calpain (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM). It also inhibits cathepsins B and L (IC50s = 15 and 1.6 nM, respectively). It is selective for these calpains and cathepsins over other cysteine and serine proteases, factor VIIa, factor Xa, trypsin, chymotrypsin, and proteasome. In an in vitro porcine model of cataract, calpain inhibitor VI decreases the degree of cataract by 40% when used at a concentration of 0.8 μM. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Calpain inhibitor VI improves functional outcome and reduces apoptotic cell death in a rat model of spinal cord injury.

SJA6017 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SJA6017 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 52)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354
 marketing@targetmol.com United States 32376 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439
 sales@nextpeptide.com China 19908 58
Nanjing TGpeptide 		+86-13347807150
support@tgpeptide.com China 3279 58
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
Changsha MOL Changes Biotechnology Co., Ltd. 		+8619375158599
 info@molchanges.com China 5220 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739
 info@dycnchem.com China 53900 58
GL Biochem (Shanghai) Ltd 21-61263452 13641803416
 ymbetter@glbiochem.com China 9981 64
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696
 info@hanhongsci.com China 42953 64
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15402 60
  • N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL
  • 4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE
  • 4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL
  • CALPAIN INHIBITOR VI
  • SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal
  • SJA6017
  • Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
  • Calpain Inhibitor 4
  • Calpain-In-4
  • Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-
  • 190274-53-4
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