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3-bromo-5-phenyl Salicylic Acid

3-bromo-5-phenyl Salicylic Acid Struktur
4906-68-7
CAS-Nr.
4906-68-7
Englisch Name:
3-bromo-5-phenyl Salicylic Acid
Synonyma:
NSC-109116;AKR1C1-IN-1;AKR1C1-IN-1, 10 mM in DMSO;XVZSXNULHSIRCQ-UHFFFAOYSA-N;3-bromo-5-phenylsalicyclic acid;3-bromo-5-phenyl Salicylic Acid;3-bromo-5-phenyl Salicylic Acid Exclusive;5-Bromo-4-hydroxy[1,1'-biphenyl]-3-carboxylic acid;5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid;[1,1'-Biphenyl]-3-carboxylic acid, 5-bromo-4-hydroxy-
CBNumber:
CB62590019
Summenformel:
C13H9BrO3
Molgewicht:
293.11
MOL-Datei:
4906-68-7.mol

3-bromo-5-phenyl Salicylic Acid Eigenschaften

Schmelzpunkt:
212-214 °C
Siedepunkt:
401.2±45.0 °C(Predicted)
Dichte
1.611±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 0.1 mg/ml
Aggregatzustand
A crystalline solid
pka
2.45±0.14(Predicted)
Farbe
White to pink
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

3-bromo-5-phenyl Salicylic Acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM). Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).

3-bromo-5-phenyl Salicylic Acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-bromo-5-phenyl Salicylic Acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 45)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656
 1059@dideu.com China 3178 58
TargetMol Chemicals Inc. 		+17819995354
 marketing@targetmol.com United States 32375 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38832 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 12952 65
BOC Sciences 16314854226
 info@bocsci.com United States 9923 65
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903
 3008007409@qq.com China 71826 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 6688 55
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
Zhengzhou Alpha Chemical Co. LTD 0371-0371-53732842 13383863444
 3002612166@qq.com China 10015 58

4906-68-7()Verwandte Suche:

  • 3-bromo-5-phenyl Salicylic Acid
  • 3-bromo-5-phenyl Salicylic Acid Exclusive
  • XVZSXNULHSIRCQ-UHFFFAOYSA-N
  • AKR1C1-IN-1
  • [1,1'-Biphenyl]-3-carboxylic acid, 5-bromo-4-hydroxy-
  • 5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • NSC-109116
  • 3-bromo-5-phenylsalicyclic acid
  • inhibit,AKR-1C1-IN-1,progesterone,AKR1C1IN1,AKR1C1 IN 1,Inhibitor,AKR1C1
  • 5-Bromo-4-hydroxy[1,1'-biphenyl]-3-carboxylic acid
  • AKR1C1-IN-1, 10 mM in DMSO
  • 4906-68-7
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