Alectinib
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- CAS-Nr.
- 1256580-46-7
- Englisch Name:
- Alectinib
- Synonyma:
- Alecensa;Alecitinib;Alectinib (CH5424802);AF-802;CS-217;canna*;RG-7853;alectinb;Aletinib;Alectinib
- CBNumber:
- CB62534680
- Summenformel:
- C30H34N4O2
- Molgewicht:
- 482.62
- MOL-Datei:
- 1256580-46-7.mol
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Alectinib Eigenschaften
- Schmelzpunkt:
- 274-276°C
- Siedepunkt:
- 722.5±60.0 °C(Predicted)
- Dichte
- 1.28
- storage temp.
- -20°
- L?slichkeit
- Soluble in DMSO (up to 5 mg/ml with warming).
- Aggregatzustand
- solid
- pka
- 13.70±0.40(Predicted)
- Farbe
- White
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.
- InChIKey
- KDGFLJKFZUIJMX-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(C#N)=C2)C2=C1C(C)(C)C1=CC(N3CCC(N4CCOCC4)CC3)=C(CC)C=C1C2=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H341 |
Kann vermutlich genetische Defekte verursachen. |
Keimzellmutagenit?t |
Kategorie 2 |
Warnung |
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P201,P202, P281, P308+P313, P405,P501 |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H373 |
Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P281 |
Vorgeschriebene pers?nliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P314 |
Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Alectinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Alectinib is another selective ALK inhibitor that is able to overcome resistance
mutations from prior crizotinib exposure [38].
Chemische Eigenschaften
White to Off-White Solid
Indications
Alectinib (Alecensa(R), Roche) was approved first in Japan in 2014 and then by US FDA in 2015 as a second-generation ALK inhibitor for NSCLC treatment on patients who have progressed or do not tolerate crizotinib. Developed through a structure-based drug design approach, alectinib is a benzocarbazolone derivative that has shown potent inhibitory activity against ALK (IC50 value of 1.9 nM) and gatekeeper mutant L1196M ALK (IC50 value of 1.6 nM). Alectinib is effective with crizotinib-resistant ALK mutations on L1196M, F1174L, R1275Q, and C1156Y. In addition, an array of small-molecule inhibitors are currently being evaluated by several clinical trials for ALK-driven tumors.
Definition
ChEBI: An organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively. Used (as the hydr
chloride salt) for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell lung cancer.
Trademarks
Alecensa?
Alectinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Alectinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 352)Lieferanten
- AF-802
- CH-5424802/RG-7853
- Alectinib
- AF-802,RG-7853
- 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802)
- CH5424802-alectinib
- 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
CH5424802
- CH5424802, Alectinib, AF802
- 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6
- 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
- 9-ETHYL-6,6-DIMETHYL-8-(4-MORPHOLINOPIPERIDIN-1-YL)-11-OXO-6,11-DIHYDRO-5H-BENZO[B]CARBAZOLE-3-CARBONITRILE
- CH5424802
- AF 802; AF-802; AF802; CH5424802; CH5424802; CH 5424802; RO5424802; RO 5424802; RO5424802, ALECTINIB; BRAND NAME: ALECENSA
- brand name: Alecensa
- RO 5424802
- RO5424802
- RO5424802, Alectinib
- RG-7853
- AF-802; CH 5424802; CH-5424802; AF802; AF 802
- alectinb
- CS-217
- Alectinib free base
- 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
- 5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-
- 9-Ethyl-6,6-dimethyl-8-(4-morpholino-1-piperidyl)-11-oxo-5H-benzobcarbazole-3-carbonitrile
- Alectinib USP/EP/BP
- 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib
- Alectinib (AF-802, CH-5424802, RO-5424802, Alecensa)
- canna*
- Alectinib (CH5424802)
- Alecensa
- Alecitinib
- Elle, on behalf of,
- Alectinib base
- Aletinib
- Alectinib, 10 mM in DMSO
- Ethyl-6,6-dimethyl-8-(4-morpholino-1-piperidyl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
- 1256580-46-7
- 1256584-03-4
- Anti-cancer&immunity
- Inhibitors
- API
- API
