Doxycycline hyclate
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Doxycycline hyclate Eigenschaften
- Schmelzpunkt:
- 206-209?C (dec.)
- alpha
- D25 -110° (c = 1 in 0.01N methanolic HCl)
- RTECS-Nr.
- QI8925000
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: soluble50mg/mL
- Aggregatzustand
- Yellow to yellow-green crystalline solid
- Farbe
- yellow to greenish-yellow
- Biologische Quelle
- synthetic
- Wasserl?slichkeit
- Soluble in water to 50mg/ml. May require warming.Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether.
- Merck
- 14,3440
- BRN
- 5702728
- InChIKey
- HALQELOKLVRWRI-VDBOFHIQSA-N
- SMILES
- C(O)C.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])[C@H](C3C=CC=C(O)C=3C(=O)C1=C2O)C)O)=O.Cl |&1:4,12,16,18,19,21,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn | ||
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R-S?tze: | 22-36/37/38 | ||
S-S?tze: | 26 | ||
WGK Germany | 3 | ||
HS Code | 29413000 | ||
Toxizit?t | LD50 i.p. in rats: 262 mg/kg (Goldenthal) |
Bildanzeige (GHS) |
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Doxycycline hyclate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.Beschreibung
Doxycycline Hyclate is the hyclate salt form of doxycycline, is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 μM. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.Chemische Eigenschaften
Doxycycline hyclate is a yellow, hygroscopic crystalline powder, freely soluble in water and in methanol, sparingly soluble in ethanol (96 per cent), it dissolves in solutions of alkali hydroxides and carbonates.Verwenden
Doxycycline hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses. Inhibits matrix metalloproteinases at subantimicrobial doses.Application
Doxycycline hyclate is a synthetic oxytetracycline derivative with similar antimicrobial activity. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases(MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling. Doxycycline hyclate has also been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).Definition
ChEBI: The hemiethanolate hemihydrate of doxycycline hydrochloride. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chroni obstructive pulmonary disease (COPD), and adult periodontitis.Weltgesundheitsorganisation (WHO)
Doxycycline, a semi-synthetic tetracycline derivative, was first introduced into medicine in 1960 for the treatment of bacterial, rickettsial and amoebic infections. Although allergic manifestations are uncommon, injectable preparations have occasionally resulted in severe anaphylactoid reactions. Clinical features and the fact that asthmatic patients seemed to be particularly at risk lead to suspect a sulfite preservative in the formulation more than doxycycline itself. Rapid administration may also be a factor. Injectable preparations of doxycycline hyclate are included in the WHO Model List of Essential Drugs.Allgemeine Beschreibung
Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.Mode of action
Tetracycline antimicrobials bind to the bacterial 30S ribosomal subunit interfering with tRNA/mRNA interaction, ultimately inhibiting protein synthesis. Tetracyclines can inhibit the MMP enzyme family and inhibit mitochondrial biogenesis.Doxycycline hyclate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Doxycycline hyclate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 639)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei ZB Gamay Biological Technology Co.,Ltd | +8617330018573 |
info@zbvet.net | China | 263 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 |
mina@chuanghaibio.com | China | 18130 | 58 |
HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD | +86-19925801629 +86-19925801629 |
eric@huarongpharma.com | China | 241 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085; +8615531157085 |
abby@chuanghaibio.com | China | 8805 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531153977 |
allison@yan-xi.com | China | 5853 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5471 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 997 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20228 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-17396673057 |
linda@tnjone.com | China | 1143 | 58 |
24390-14-5()Verwandte Suche:
N,N-Dimethylpyridin-4-amin
Methoxyammoniumchlorid
Aminocapronsure
Glucosaminhydrochlorid
4-Dimethylaminobenzoesure
Glycin
N,N-Dimethyl-1,3-diaminopropan
Oxytetracycline dihydrate
1,4-Dioxan
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
Trometamol
Topotecan hydrochloride
ALTRENOGEST
oxytetracyclin
Triethylammoniumchlorid
Pyridiniumchlorid
Oxytetracyclinhydrochlorid
4-Dimethylamino-benzaldehyd
- 4-(DIMETHYLAMINO)-1,4,4 ALPHA,5,5 ALPHA,6,11,12 ALPHA-OCTAHYDRO-3,5,10,12,12 ALPHA-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE, MONOHYDRATE
- 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NA
- Doxycycline monohydrate BP2000/Ph Eur 4/USP25
- DOXYCYCLINE HYDROCHLORIDE, VETRANAL
- Doxycycline Hyclate USP
- DOXYCYCLINE HYCLATE USP GRADE
- (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamidehydrochloride
- Doxycycline Hc1
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol (2:1), monohydrate
- Doxycycline Hyclate / Monohydrate
- 2-(Amino-hydroxy-methylidene)-4-dimethylamino-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione hydrochloride hemiethanolate
- Doxycycline hyclate
- Doxycycline hydrochloride hemiethanolate
- DOXYCYCLINE HYCLATE, =98% (HPLC)
- 4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydr
- Doxycycline for system suitability
- Hydrochloride hemiethanolate hemihydrate
- Doxycycline Hyclate (200 mg)J0E174859ug/mg(ai)
- Doxycycline Hyclate (200 mg)
- Doxycycline HCl DISCONTINUED Replaced by D5897
- (4S,4aR,5S,5aR,6R,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro -3,5,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-
- Doxycycline API
- Doxycycline hyclate COS
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol, hydrate (2:2:1:1)
- Doxycycline hyclate Solution, 100ppm
- Doxycycline hyclate, BP
- Doxycycline hydrochloride hemiethanolate hemihydrate, Antibiotic for Culture Media Use Only
- Doxycycline Hyclate/HCL
- (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate
- Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem
- Doxycycline hyclate, ≥98%
- Doxycycline hyclate, ≥94%
- WC2031
- DoxycyclineHyclate>
- Doxycycline for system suitability CRS
- DoxycycL
- ine hycL
- Doxycline Hydrochloride
- (2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
- Doxycycline Hydrochloride?I
- oxycyclinehyclate
- Doxycycline hyclate USP/EP/BP
- (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide compound with ethanol (2:1) dihydrochloride hydrate
- Doxycycline-D4-Hyclate
- Doxycycline D5 HyclateQ: What is Doxycycline D5 Hyclate Q: What is the CAS Number of Doxycycline D5 Hyclate
- Doxycycline for system suitability (Y0001714)Q: What is Doxycycline for system suitability (Y0001714) Q: What is the CAS Number of Doxycycline for system suitability (Y0001714)
- Doxycycline HyclateQ: What is Doxycycline Hyclate Q: What is the CAS Number of Doxycycline Hyclate Q: What is the storage condition of Doxycycline Hyclate Q: What are the applications of Doxycycline Hyclate
- Doxycycline D2 Hyclate majorQ: What is Doxycycline D2 Hyclate major Q: What is the CAS Number of Doxycycline D2 Hyclate major Q: What is the storage condition of Doxycycline D2 Hyclate major Q: What are the applications of Doxycycline D2 Hyclate major
- Doxycycline hyclate (DXH) for biochemistry & microbiology
- Doxycycline Hyclate (1226003)
- Doxycycline Hydrochlocide
- DOXYCYCLINE HYDRATE
- Doxycycline hyclate CRS
- Doxycycline Hyclate Soluble Powder
- 6α-Deoxy-5-hydroxytetracycline
- (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hemiethanol dihydrochloride hemihydrate
- Doxycycline (50mg/ml)
- DOXYCYCLINE HYCLATE 50% W/W PELLETS