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Alpelisib (BYL719)

Alpelisib (BYL719) Struktur
1217486-61-7
CAS-Nr.
1217486-61-7
Englisch Name:
Alpelisib (BYL719)
Synonyma:
Alpelisib;Piqray;BYL-719;CS-614;100803;BLV-719;BYL-719 /BYL719;Alpelisib (BYL719);BYL-719(Alpelisib);Alpelisib (BLY-719
CBNumber:
CB52604234
Summenformel:
C19H22F3N5O2S
Molgewicht:
441.47
MOL-Datei:
1217486-61-7.mol

Alpelisib (BYL719) Eigenschaften

Dichte
1.391
storage temp. 
Store at -20°C
L?slichkeit
≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Aggregatzustand
White solid.
pka
6.29±0.70(Predicted)
Farbe
Off-white to light yellow
InChIKey
STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES
N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  29341000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P314 Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Alpelisib (BYL719) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.

Trademarks

Piqray

Synthese

Synthesis of Alpelisib (BYL719)
Alpelisib (BYL719) synthesis

Alpelisib (BYL719) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Acetamide,N-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]- 4-Methyl-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-methyl-2-(2,2,2-trifluoro-1-methyl-1-trimethylsilanyloxy-ethyl)pyridine 1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-ol 1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-yl methanesulfonate N-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)-1H-iMidazole-1-carboxaMide phenyl 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-ylcarbamate (S)-Pyrrolidin-2-carboxamid 1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one 2-Acetyl-4-methylpyridine 2,4-Dimethylpyridin

Downstream Produkte

Alpelisib (BYL719) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 264)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 +86-13986145403;
 info@fortunachem.com China 5946 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500
 nickzhang@hangyubiotech.com China 10985 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368
sales@sjar-tech.com China 485 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317
 jiuyitime@fdachem.com China 6614 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29855 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19552 58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd 		029-81140587 +8618717328141
 sales@yutbon.com China 454 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196
 sale04@alfachem.cn China 12438 58

1217486-61-7()Verwandte Suche:

  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • BYL-719 /BYL719
  • BLV-719
  • (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide
  • 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-
  • Alpelisib (BYL719)
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719
  • BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • BYL-719(Alpelisib)
  • (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolid
  • ALPELISIB;BYL-719; BYL 719
  • CS-614
  • Alpelisib - NVP-BYL719 | BYL-719
  • 100803
  • (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
  • Alpelisib, 98%, a potent and selective PI3Kα inhibitor
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ISO 9001：2015 REACH
  • Alpelisib (BLY-719
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidine
  • BYL-719
  • Alpelisib
  • Piqray
  • Inhibitor,Phosphoinositide 3-kinase,PI3K,Alpelisib,inhibit,phosphorylation,p110α,cancer,BYL 719,antineoplastic,AKT,metastasis,mutant,BYL719,PIK3CA,breast
  • (2S) - N1- [4-methyl-5- [2- (2,2,2-trifluoro-1,1-dimethylethyl) -4-pyridyl] -2-thiazolyl] -1,2-pyrrolidine dicarboxylamide
  • Biopterin Impurity 2
  • Alpelisib, 10 mM in DMSO
  • Byl-719/Alpelisib, Free Base
  • (2S)-1-N-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide - [AC77664]
  • 1217486-61-7
  • C19H22F3N5O2S
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
  • PI3K/Akt/mTOR
  • Api
  • API
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