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1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone

1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Struktur
821794-92-7
CAS-Nr.
821794-92-7
Englisch Name:
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
Synonyma:
FMK;FMK, 10 mM in DMSO;Fluoromethyl Ketone;RSK2 kinase inhibitor;FMK - RSK inhibitor Fmk;Fluoromethyl Ketone-MEA, FMK-MEA;1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone;1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone;Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-;1-[5-amino-9-(3-hydroxypropyl)-7-(4-methylphenyl)-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-8-yl]-2-fluoro-ethanone
CBNumber:
CB51161837
Summenformel:
C18H19FN4O2
Molgewicht:
342.37
MOL-Datei:
821794-92-7.mol

1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Eigenschaften

Dichte
1.36
storage temp. 
Store at -20°C
L?slichkeit
insoluble in H2O; ≥17.1 mg/mL in DMSO; ≥28.7 mg/mL in EtOH
Aggregatzustand
solid
Farbe
White to light yellow
InChI
InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22)
InChIKey
IKLGYJACVCXYIL-UHFFFAOYSA-N
SMILES
C(=O)(C1N(CCCO)C2C(C=1C1=CC=C(C)C=C1)=C(N)N=CN=2)CF

Sicherheit

HS Code  2933998090

1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

FMK is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.

1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 77)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 965 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19552 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29804 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471
sales@sarms4muscle.com China 10473 58
Henan Alfa Chemical Co., Ltd 		+8615838112936
 alfa10@alfachem.cn China 13006 58
LEAP CHEM CO., LTD. 		+86-852-30606658 19957148339;
 market18@leapchem.com China 24727 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
  • 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
  • 1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-fluoroethanone
  • RSK2 kinase inhibitor
  • FMK
  • FMK - RSK inhibitor Fmk
  • Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-
  • 1-[5-amino-9-(3-hydroxypropyl)-7-(4-methylphenyl)-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-8-yl]-2-fluoro-ethanone
  • Fluoromethyl Ketone
  • Fluoromethyl Ketone-MEA, FMK-MEA
  • FMK, 10 mM in DMSO
  • 821794-92-7
  • Akt
  • mTOR
  • PI3K
  • API
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