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Remibrutinib

Remibrutinib Struktur
1787294-07-8
CAS-Nr.
1787294-07-8
Englisch Name:
Remibrutinib
Synonyma:
LOU064;LOU-064;REMIBRUTINIB;Lou064/Remibrutinib;Remibrutinib (LOU064);Remibrutinib, 10 mM in DMSO;Remibrutinib (LOU064) ，S9660;Btk,Inhibitor,inhibit,Remibrutinib,Bruton tyrosine kinase;N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide;N-(3-{5-[2-(Acryloyl-methyl-amino)-ethoxy]-6-amino-pyrimidin-4-yl}-5-fluoro-2-methyl-phenyl)-4-cyclopropyl-2-fluoro-benzamide
CBNumber:
CB44675356
Summenformel:
C27H27F2N5O3
Molgewicht:
507.53
MOL-Datei:
1787294-07-8.mol

Remibrutinib Eigenschaften

Siedepunkt:
634.8±55.0 °C(Predicted)
Dichte
1.332±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO: 125 mg/mL (246.29 mM)
Aggregatzustand
Solid
pka
11.67±0.70(Predicted)
Farbe
White to off-white
InChIKey
CUABMPOJOBCXJI-UHFFFAOYSA-N
SMILES
C(NC1=CC(F)=CC(C2C(OCCN(C)C(=O)C=C)=C(N)N=CN=2)=C1C)(=O)C1=CC=C(C2CC2)C=C1F

Sicherheit

Remibrutinib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib has the potential for Chronic urticaria (CU) treatment.

Remibrutinib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Remibrutinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 70)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354
 marketing@targetmol.com United States 32376 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658
 sales1@artkmedchem.com China 39003 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
Shanghai Hanhong Scientific Co., Ltd. 		+undefined17612118332
 Lucky@hanhonggroup.com China 6035 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581
 sales@chemhifuture.com China 5686 58
Shanghai XingMo Biotechnology Co., Ltd. +86 13524779951; 13524779951
 2075692521@qq.com China 310 55
Shanghai Hope Chem Co., Ltd.， +21-18501659228 18501659228
 info@hope-chem.com China 483 55
  • Remibrutinib (LOU064)
  • LOU064
  • LOU-064
  • REMIBRUTINIB
  • N-(3-{5-[2-(Acryloyl-methyl-amino)-ethoxy]-6-amino-pyrimidin-4-yl}-5-fluoro-2-methyl-phenyl)-4-cyclopropyl-2-fluoro-benzamide
  • Benzamide, N-[3-[6-amino-5-[2-[methyl(1-oxo-2-propen-1-yl)amino]ethoxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluoro-
  • N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide
  • Btk,Inhibitor,inhibit,Remibrutinib,Bruton tyrosine kinase
  • N-[3-[6-Amino-5-[2-[methyl(1-oxo-2-propen-1-yl)amino]ethoxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide
  • Remibrutinib, 10 mM in DMSO
  • Lou064/Remibrutinib
  • Remibrutinib (LOU064) ，S9660
  • 1787294-07-8
  • C27H27F2N5O3
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