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(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Struktur
177943-33-8
CAS-Nr.
177943-33-8
Englisch Name:
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
Synonyma:
PF-04859989HCl;PF-04859989 HCl;PF04859989 hydrochloride;PF-4859989 hydrochloride;PF-04859989 hydrochloride;PF-04859989 HCl, 10 mM in DMSO;PF-04859989 hydrochloride >=98% (HPLC);(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one;(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one;L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
CBNumber:
CB42598844
Summenformel:
C9H11ClN2O2
Molgewicht:
214.64884
MOL-Datei:
177943-33-8.mol

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Eigenschaften

storage temp. 
room temp
L?slichkeit
H2O: soluble20mg/mL, clear
Aggregatzustand
powder
Farbe
white to beige
Wasserl?slichkeit
Water: 22 mg/ml

Sicherheit

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 32)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+17819995354
 marketing@targetmol.com United States 32375 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861
 contact@labnetwork.com China 19987 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860
 anhua.mao@aladdin-e.com China 25003 65
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51395 80
ShangHai Angti Biotechnology Co., Ltd. 13764913901
 info@angtibio.com China 5002 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903
 3008007409@qq.com China 71826 60
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 17801761073
 3193328036@qq.com China 29763 68
Tianjin heowns Biochemical Technology Co., Ltd. 400-638-7771 18920794737
 sales@heowns.com China 23623 60
  • (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
  • (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one
  • L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
  • PF04859989 hydrochloride
  • PF-04859989 hydrochloride
  • PF-4859989 hydrochloride
  • PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
  • PF-04859989 hydrochloride >=98% (HPLC)
  • 2(1H)-Quinolinone, 3-amino-3,4-dihydro-1-hydroxy-, monohydrochloride, (S)- (9CI)
  • (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one
  • PF-04859989 HCl
  • PF-04859989HCl
  • disorders,schizophrenia,Inhibitor,inhibit,PF04859989 HCl,midbrain,psychiatric,PF 04859989 HCl,dopamine,neurons,cognitive ,impairment
  • PF-04859989 HCl, 10 mM in DMSO
  • 177943-33-8
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