1,2-Methylendioxybenzol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/22:Gesundheitssch?dlich beim Einatmen und Verschlucken.
R22:Gesundheitssch?dlich beim Verschlucken.
R10:Entzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
1,3-Benzodioxole, widely found in plant products, has shown potent antioxidant and antibacterial activities. It has recently been reported that 1,3-benzodioxole derivatives possess cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells. No cytotoxic effects were noticed at a concentration of 10-4 M.
Chemische Eigenschaften
clear colourless to light yellow liquid. Insoluble in acids.
Verwenden
1,3-Benzodioxole is useful in gemological stimulant detection. It is also used as a precursor for perfumes, photo initiators, agrochemicals and pharmaceuticals. 1,3-benzodimine is an intermediate for the synthesis of the drugs oxolinic acid, cinoxacin and miloxacin.
Vorbereitung Methode
1,3-Benzodioxole is synthesized through the reaction of catechol with dihalomethanes, typically employing a concentrated aqueous alkaline solution in the presence of tetraalkylammonium or phosphonium salts, sometimes in the presence of alkyl iodides. 1,3-Benzodioxole is an important intermediate in organic synthesis, especially for the preparation of alkaloids.
Application
1,3-Benzodioxole belong to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P 450-dependent drug oxidation, which is important in the process of eliminating drugs from the body. a hydrogen abstraction process can take place from the methylene-bridgea carbon of the benzodioxole compound and form a methylenedioxybenzene radical. It is therefore highly likely that 1,3-benzodioxole could serve as hydrogen donor for a CQ-based system initiating the photopolymerization of dental composite resin. In addition, 1,3-benzodioxole is an important organic intermediate (building block) to synthetize substituted methylenedioxybenzene products.
Definition
ChEBI: 1,3-benzodioxole is a benzodioxole consisting of a benzene ring substituted by a the methylenedioxy group.
Allgemeine Beschreibung
Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied. The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported. The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated.
1,2-Methylendioxybenzol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Chlor-1,3-benzodioxol
3,4-METHYLENEDIOXYPHENYL ISOTHIOCYANATE
3,4-(Methylendioxy)phenylacetonitril
1,2-(Methylendioxy)-4-nitrobenzol
Piperonal
4-Nitrobrenzcatechin
PIPERONYL FORMALDEHYDE
3-Ethoxy-4-hydroxybenzaldehyd
Benzo-1,3-dioxol-5-ethylamin
(+/-)-1-(1,3-Benzodioxol-5-yl)-2-broMo-1-pentanone
5-CHLORO-1,3-BENZODIOXOLE
N,N,N',N'-Tetraethylmethylendiamin
3,4-(METHYLENEDIOXY)BUTYROPHENONE
1,3-BENZODIOXOLE-4-CARBOXYLIC ACID
