6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on
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6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on Eigenschaften
- Schmelzpunkt:
- 73-75°C
- alpha
- D20 -129.0° (c = 1 in chloroform)
- Siedepunkt:
- 501.11°C (rough estimate)
- Dichte
- 1.2350 (rough estimate)
- Brechungsindex
- 1.5614 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: 10 mg/mL
- Aggregatzustand
- powder
- pka
- 8.48±0.40(Predicted)
- Farbe
- White to off-white
- Sensitive
- Air & Light Sensitive
- BRN
- 2822892
- Stabilit?t:
- Hygroscopic
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T,T+ | ||
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R-S?tze: | 25-26/27/28 | ||
S-S?tze: | 22-24/25-45-36/37/39 | ||
RIDADR | UN 2811 6.1/PG 2 | ||
WGK Germany | 3 | ||
RTECS-Nr. | GH0800000 | ||
F | 8-10-23 | ||
HazardClass | 6.1(a) | ||
PackingGroup | II | ||
Toxizit?t | LD50 oral in mouse: 25530ug/kg |
Bildanzeige (GHS) |
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Alarmwort | Achtung | ||||||||||||||
Gefahrenhinweise |
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Sicherheit |
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6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Colcemid is a colchicine derivative that inhibits tubulin polymerization as potently as colchicine (IC50 = 2.1 and 2.4 μM, respectively) but is less toxic. At very low (nanomolar) concentrations, colcemid suppresses microtubule dynamicity and inhibits cell migration, while at micromolar levels it blocks microtubule assembly, arresting cells in metaphase. Mitotic block by colcemid is used to synchronize cells and for karyotyping in cytogenetic studies. Prolonged exposure to colcemid can activate p53, leading to apoptosis.Chemische Eigenschaften
Faintly Yellow Crystalline PowderVerwenden
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.Definition
ChEBI: A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than olchicine and is used as an antineoplastic.Allgemeine Beschreibung
Colcemid is also known as demecolcine. Its generic name is N-methyl-N-deacetyl-colchicine. Colcemid depolymerizes microtubules and blocks mitosis at metaphase.Sicherheitsprofil
Poison by ingestion, intraperitoneal, parenteral, intravenous, and intramuscular routes. Human systemic effects by ingestion: (skin and appendages) hair effects. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.l?uterung methode
Colcemide is purified by chromatography on silica and eluting with CHCl3/MeOH (9:1), and by recrystallisation from EtOAc/Et2O to form yellow prisms. UV in EtOH has max 243nm ( 30,200) and 350nm ( 16,3000). [Synthesis, IR, NMR, MS: Capraro & Brossi Helv Chim Acta 62 965 1979, Beilstein 8 IV 3319.]6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 149)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 |
1059@dideu.com | China | 3178 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20202 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29804 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32376 | 58 |
Wuhan Monad Medicine Tech Co.,LTD | 02768782018 18771942761 |
sales01@whmonad.com | CHINA | 979 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23541 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 22354 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 |
info@dycnchem.com | China | 52846 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49983 | 58 |
477-30-5(6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on)Verwandte Suche:
- substancef
- Colcemide
- DEMECOLCINE HYBRI-MAXR
- Colcemid-D3=Demecolcine-D3
- N-Deacetyl-N-methyl(deutero)colchicine
- COLCEMIDE(R)
- COLCEMID(R)
- DEMECOLCIN
- DEMECOLCINE
- Benzoaheptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)-
- COLCHICINE,N-DEACETYL-N-METHYL-
- DEMECOLCINE/COLCEMIDE/COLCHICINE
- N-Deacetyl-N-methylcolchicine, Colcemid
- ColcemidTM solution, N-Deacetyl-N-methylcolchicine solution
- Demecolcine solution
- C-12669
- Osamin
- Demecolcine,N-Deacetyl-N-methylcolchicine
- Colcemid, Demecolcine
- (7S)-6,7-Dihydro-1,2,3,10-tetraMethoxy-7-(MethylaMino)-benzo[a]heptalen-9(5H)-one
- ColchaMin
- 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo(alpha)heptalen-9(5h)
- 7-deacetamido-7-(methylamino)-colchicin
- alkaloidh3,fromcolchicumantumnale
- benzo(a)heptalen-9(5h)-one,6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)
- ciba12669a
- deacetylmethylcolchicine
- deacetyl-n-methyl-colchicin
- deacetyl-n-methylcolchicine
- desmecolcine
- kolchamin
- kolchicin
- n-deacetyl-n-methyl-colchicin
- n-desacetylmethylcolchicine
- n-methyl-n-desacetylcolchicine
- nsc3096
- omain
- omaine
- reichstein’sf
- santavy’ssubstancef
- N-DEACETYL-N-METHYLCOLCHICINE
- N-DESACETYL-N-METHYLCOLCHICINE
- N-METHYL-N-DEACETYL-COLCHICINE
- DEMECOLCINE SOLUTION 10 UG/ML
- Colcemid - CAS 477-30-5 - Calbiochem
- Colchicine N-Methyl Analog
- (-)-demecolcine
- DEMECOLCINE USP/EP/BP
- Decarbonylation colchicine
- Demecolcine, ≥98%+
- Tropisetronum
- Tropisteron
- COLCEMID
- COLCHAMINE
- (S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
- Colchicine Impurity 23
- Demecolcine in methanol
- Chelidonine Impurity?3