Anti-Amplified in osteosarcoma 9 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-OS9 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Allgemeine Beschreibung
OS9 endoplasmic reticulum lectin is encoded by the gene mapped to human chromosome 12q13.3-q14.1. Alternative splicing of the OS-9 gene yields two proteins, namely OS-9.1 and OS-9.2. These proteins are ubiquitously expressed in human tissues.
Biochem/physiol Actions
OS9 endoplasmic reticulum lectin is an endoplasmic reticulum (ER)-resident lectin involved in ER quality control. OS9 is upregulated in response to ER stress through activation of the Ire1/Xbp1 pathway. OS9 associates both with components of the ERAD machinery and ERAD substrates. OS9 binds to misfolding proteins and prevents their secretion from the ER. It then directs them to the suppressor/enhancer of Lin-12-like (Sel1L) / hydroxymethylglutaryl reductase degradation protein 1 (Hrd1) dislocation and ubiquitylation complex in the ER membrane. Two OS9 spliced variants, OS-9.1 and OS-9.2 expressions are amplified in tumors.
Anti-Amplified in osteosarcoma 9 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
