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R-(+)-1-(1-Naphthyl)ethylamin

(R)-(+)-1-(1-Naphthyl)ethylamine Struktur
3886-70-2
CAS-Nr.
3886-70-2
Bezeichnung:
R-(+)-1-(1-Naphthyl)ethylamin
Englisch Name:
(R)-(+)-1-(1-Naphthyl)ethylamine
Synonyma:
(R)-1-(1-NAPHTHYL)ETHYLAMINE;(R)-1-(NAPHTHALEN-1-YL)ETHANAMINE;CINACALCET intermediate;C12Hj3N;(R)-(+)-ALPH;Cinacalcet-21;RNEA IMPURITY;Ivocase impurity 6;R-Napthylethylamine;Cinacalce Impurity A
CBNumber:
CB3210204
Summenformel:
C12H13N
Molgewicht:
171.24
MOL-Datei:
3886-70-2.mol

R-(+)-1-(1-Naphthyl)ethylamin Eigenschaften

Schmelzpunkt:
135-136 °C
Siedepunkt:
153 °C11 mm Hg(lit.)
alpha 
60 º (c=2, CH3OH)
Dichte
1.067 g/mL at 20 °C(lit.)
Brechungsindex
n20/D 1.623(lit.)
Flammpunkt:
>230 °F
storage temp. 
2-8°C
L?slichkeit
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
Aggregatzustand
Liquid
pka
9.26±0.40(Predicted)
Wichte
1.07
Farbe
brown
Optische Rotation
[α]20/D +55°, c = 2 in ethanol
Wasserl?slichkeit
Soluble in water (<10/l).
Sensitive 
Air Sensitive
BRN 
2208025
Stabilit?t:
Stable. Air-sensitive. Incompatible with acids, oxidizing agents, acid anhydrides, chloroformates, acid chlorides.
InChIKey
RTCUCQWIICFPOD-SECBINFHSA-N
CAS Datenbank
3886-70-2(CAS DataBase Reference)
EPA chemische Informationen
1-Naphthalenemethanamine, .alpha.-methyl-, (.alpha.R)- (3886-70-2)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
RIDADR  2735
WGK Germany  3
RTECS-Nr. QJ6963000
10-34
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29211990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

R-(+)-1-(1-Naphthyl)ethylamin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

(R)-(+)-1-(1-Naphthyl)ethylamine is a reagent used in the formation of isolated acids via salt formation. It is also a raw material for the synthesis of (R)-1-(1-Naphthyl)ethyl isocyanate. In materials research, the use of Reflectance Absorption Infrared Spectroscopy (RAIRS) can be used to study the structure, bonding and orientation of R-1- nea and (S)-(-)-1-(2-naphthyl)ethylamine (S-2- nea) on Pd(1 1 1).

Chemische Eigenschaften

Colorless to light yellow liqui

Verwenden

(R)-(+)-1-(1-Naphthyl)ethylamine is a key intermediate in the synthesis of the chiral drug cinacalcet (trade name: Sensipar) and also an important intermediate in the synthesis of a coronavirus PLpro protease inhibitor. (R)-(+)-1-(1-Naphthyl)ethylamine and (S)-(-)-1-(1-naphthyl)ethylamine both belong to the class of chiral aromatic amine separators and have broad application prospects in fields such as chiral drugs and chiral pesticides.

synthetische

There are three main methods for preparing (R)-(+)-1-(1-Naphthyl)ethylamine: (1) Enzymatic separation method; (2) Chemical separation method, with the following separation agents used: chiral aspartic acid, chiral α-hydroxy naphthoic acid, protective chiral glycerol derivatives, and chiral tartaric acid; (3) Dissymmetric synthesis, etc. Using dissymmetric synthesis as an example, obtain Chiral Amine to prochiral ketone oxime through asymmetric catalytic hydrogenation reduction, method adopts ammonium formiate to reduce by 1-(1-naphthyl) acetophenone oxime, at chlorine { [(1R, 2R)-(-)-2-ammonia-1,2-Diphenethyl] (4-tolylsulfonyl) ammonia (p-isopropyl toluene) ruthenium (II)) catalyzer exist under, adopt polar solvent as dimethyl formamide, methyl alcohol, ethanol, n-propyl alcohol, Virahol, butanols, the one in the trimethyl carbinol.Catalytic asymmetric reduction single step reaction preparation (R)-(+)-1-(1-naphthyl) ethamine is carried out to 1-(1-naphthyl) acetophenone oxime.

Application

Absolute configuration of primary amines determined using chiral (2-nitrophenyl)proline amides and 1H NMR.

Allgemeine Beschreibung

(R)-(+)-1-(1-Naphthyl)ethylamine is a chiral derivatization reagent useful for all gas chromatography (GC) applications in the chiral field. It is specially selected to meet the requirements for derivatization reagents for enantiomeric excess determinations.

Solubility in organics

(R)-(+)-1-(1-Naphthyl)ethylamine is soluble in chloroform and ethanol. Insoluble in water.

l?uterung methode

Purify the amine by distillation in a good vacuum. [Mori et al. Tetrahedron 37 1343 1981, cf Wilson in Topics Stereochem (Allinger and Eliel eds) v o l 6 135 1971, Fredga et al. Acta Chem Scand 11 1609 1957.] The hydrochlorides crystallise from H2O [] D 18 ±3.9o (c 3, H2O), and the sulfates recrystallise from H2O as tetrahydrates m 230-232o. The RS-amine has b 153o/11mm, 156o/15mm, 183.5o/41mm [Blicke & Maxwell J Am Chem Soc 6 1 1780 1939]. [Beilstein 12 III 3111.]

R-(+)-1-(1-Naphthyl)ethylamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


R-(+)-1-(1-Naphthyl)ethylamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 572)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Yangzhou Qinyuan Pharmatech Co.,ltd
+86-18752526868 +86-18752526868
jennysun@yzqyyykj.com China 83 58
Jinan Dexinjia Bio&Tech Co., Ltd
+86-0531-82375818 +86-15064153060
sales@jndxj.com China 1358 58
Hebei Chuanghai Biotechnology Co., Ltd
+8617732866630
abby@chuanghaibio.com China 8773 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387
1057@dideu.com China 3944 58
Hebei Mujin Biotechnology Co.,Ltd
+8613288715578
sales@hbmojin.com China 12644 58
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5251 58
Changzhou Rokechem Technology Co., Ltd.
18758118018
sales001@rokechem.com China 255 58
hebei hongtan Biotechnology Co., Ltd
+852-6619 3215 +86-17731935328
sales03@chemcn.cn China 970 58
Capot Chemical Co.,Ltd.
+8613336195806
sales@capot.com China 29731 60

3886-70-2(R-(+)-1-(1-Naphthyl)ethylamin)Verwandte Suche:


  • (R) 1-(1-NAPTHYL)ETHYLAMINE
  • (R)-(+)-1-(1-NAPHTHYL)ETHYLAMINE
  • (R)-(+)-1-(NAPHTHYL)ETHYLAMINE
  • (R)-(+)-A-(1-NAPHTHYL)ETHYLAMINE
  • (R)-(+)-ALPHA-(1-AMINOETHYL)NAPHTHALENE
  • (R)-(+)-ALPHA-(1-NAPHTHYL)ETHYLAMINE
  • D-A-(1-NAPHTHYL)ETHYLAMINE
  • (+)-1-[(R)-1-Aminoethyl]naphthalene
  • (1R)-1-(1-Naphthyl)ethanamine
  • (R)-α-Methylnaphthalene-1-methanamine
  • (αR)-α-(1-Naphthyl)ethanamine
  • [R,(+)]-α-Methyl-1-naphthalenemethanamine
  • 1-Naphthalenemethanamine, alpha-methyl-, (R)-
  • (theta)-1-naphthalenemethanamine
  • Cinacalcet Intermediate 3
  • (R)-(+)-alpha-(Naphthalen-1-yl)ethanaMine
  • (R)-(+)-ALPHA-(1-AMINOETHYL)NAPHT
  • (1R)-(+)-1-(Naphth-1-yl)ethylamine
  • (R)-(+)-alpha-(1-Naphthyl)ethylaMine, 99+% 1GR
  • (R)-1-(naphthalene-1-yl)ethanaMine
  • (R)-(+)-1-(1-Naphthyl)ethylaMine SynonyMs R-(+)-alpha-(1-Naphthyl)ethylaMine
  • (1R)-1-(naphthalen-1-yl)ethan-1-amine
  • Cinacalcet Impurity A
  • (R)-(+)-1-(1-phthyl)ethylamine
  • (R)-1-(1-naphthyl)ethylamine,99%e.e.
  • (1R)-(1-NAPHTHALEN-1-YL)ETHANAMINE
  • (theta)-1-naphthalenemethanamin
  • (R)-(+)-α-Methyl-1-naphthalenemethylamine
  • R-PLUS-A-1-NAPHTHYL-ETHYLAMINE
  • (R)-(+)-1-(1-NAPHTHYL)ETHYLAMINE 99%
  • (R)-(+)-1-(Napthyl)ethylamine, 99%
  • (R)-(+)-alpha-(1-Naphthyl)ethylamine, 99+%
  • 1-Naphthalenemethanamine, .alpha.-methyl-, (.alpha.R)-
  • (R)-(+)-1-(Naphth-1-yl)ethylamine
  • (R)-(+)-1-(1-Naphthyl)ethylamine, ChiPros 99+%, ee 98+%
  • (R)-(+)-α-(1-Naphthyl)ethylamine, 99+%
  • R-(+)-NAPHTHYLETHYLAMINE
  • (R)- (+)--(1-NAPHTHYL) ETHYLAMINE 98%
  • Cinacalce Impurity A
  • R-NAPHTHALENEYL METHYL-1-PHENYLETHYLAMINE
  • (R)-(+)-ALPH
  • (R)-1-(Naphthalen-1-yl)ethanamine HCl
  • R-Napthylethylamine
  • (R)-(+)-1-(1-Naphthyl)ethylami
  • Cinacalcet-21
  • (R)-(+)-1-(1-NaphthyL
  • (R)-(+)-1-(1-Naphthyl)ethylamine>
  • (R)-(+)-1-(1-Naphthyl)ethylamine Cinacalcet Impurity A
  • 1-Naphthalenemethanamine, α-methyl-, (αR)-
  • (R)-(+)-α-(1-Naphthyl)ethylamine
  • (R)-(+)-1-(1-Naphthyl)ethylamine ISO 9001:2015 REACH
  • (R)-1-(Naphthalen-1-yl)ethanamine (Cinacalcet Impurity)
  • Cinacalcet Impurity A (Cinacalcet Amine Impurity)
  • Cinacalcet Impurity AQ: What is Cinacalcet Impurity A Q: What is the CAS Number of Cinacalcet Impurity A Q: What is the storage condition of Cinacalcet Impurity A Q: What are the applications of Cinacalcet Impurity A
  • (R)-1-(1-NAPHTHYL)ETHYLAMINE
  • (R)-1-(NAPHTHALEN-1-YL)ETHANAMINE
  • CINACALCET intermediate
  • (R)-1-(1-Naphthalenyl)ethylamine
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