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Fmoc-GGFG-Dxd

Fmoc-GGFG-Dxd Struktur
1599440-11-5
CAS-Nr.
1599440-11-5
Englisch Name:
Fmoc-GGFG-Dxd
Synonyma:
Fmoc-GGFG-Dxd;Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-Fmoc;Glycinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-;(S)-2-[2-[2-(Fmoc-amino)acetamido]acetamido]-N-[2-[[[2-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]amino]-2-oxoethyl]-3-phenylpropanamide;(S)-2-[2-[2-(Fmoc-amino)acetamido]acetamido]-N-[2-[[[2-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]amino]-2-oxoethyl]-3-phenylpropanamide;(9H-Fluoren-9-yl)methyl ((S)-10-benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl)carbamate
CBNumber:
CB29806179
Summenformel:
C57H55FN8O12
Molgewicht:
1063.09
MOL-Datei:
1599440-11-5.mol

Fmoc-GGFG-Dxd Eigenschaften

Dichte
1.49±0.1 g/cm3(Predicted)
Aggregatzustand
Solid
pka
10.61±0.46(Predicted)
Farbe
Light yellow to yellow
InChIKey
DLIJZDSGDLLJKM-XWCAFGSDSA-N

Sicherheit

Fmoc-GGFG-Dxd Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fmoc-GGFG-Dxd, also known as N-((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)-2-hydroxyacetamide, is a brown powder. It is a hexacyclic chemical compound analogous to camptothecin with a triplet amino acid chain linked to a terminal Fmoc group. GGFG (glycyl-glycyl-phenylalanyl-glycine peptide could link exatecan derivative (DXd) through cysteine residues. DXd is highly membrane-permeable and exhibited strong bystander killing in-vitro co-culture of HER2 positive (KPL-4) and negative (MDA-MB-468) cells and in mice inoculated with a mixture of HER2 (+) and HER2 (?) cells.
Fmoc-GGFG-Dxd

Fmoc-GGFG-Dxd Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Fmoc-GGFG-Dxd Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 15)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Xilinglab Co., Ltd.
+8618381337976
 bd@xilinglab.com China 86 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471
sales@sarms4muscle.com China 10473 58
Shanghai Tekanbio Pharm-Tech Co., Ltd. 021-50896099 18017206244
 sales@tekanbio.com China 108 58
BioPharmaMatrix,Inc. 0510-86010668
sales@biopharmamatrix.com China 4678 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136
 Sales@ATKchemical.com China 9364 58
Shochem(Shanghai)Co.,Ltd +86-021-51783479 +86-13816874662
 info@shochem.com China 307 58
Bide Pharmatech Ltd. 400-1647117 13681763483
 product02@bidepharm.com China 62320 58
Shanghai Easy CDMO Co.,Ltd 021-61734564 13854185395;
 info@easycdmo.com China 10030 58
Shaoyuan Technology (Shanghai) Co., Ltd. 021-50795510 4000665055
 sy-c6@accelachem.com China 10000 58
Jilin Chinese Academy of Sciences-yanshen Technology 18143011203
 ET-market@chemextension.com China 29341 58
  • Glycinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-
  • Fmoc-GGFG-Dxd
  • Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-Fmoc
  • (S)-2-[2-[2-(Fmoc-amino)acetamido]acetamido]-N-[2-[[[2-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]amino]-2-oxoethyl]-3-phenylpropanamide
  • (S)-2-[2-[2-(Fmoc-amino)acetamido]acetamido]-N-[2-[[[2-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]amino]-2-oxoethyl]-3-phenylpropanamide
  • (9H-Fluoren-9-yl)methyl ((S)-10-benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12,15-pentaoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-yl)carbamate
  • 1599440-11-5
  • C57H55FN8O12
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