[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
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- CAS-Nr.
- 446299-81-6
- Englisch Name:
- [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
- Synonyma:
- OzoxacinIntermediateD;Ozenoxacin Impurity 7;Ozenoxacin Impurity 15;5-Methyl-6-(phenacylamino)pyridin-3-yl]boronic acid;(5-methyl-6-(N-methylbenzamido)pyridin-3-yl)boronic acid;[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid;[6- [benzoyl (methyl) amino] -5-methyl-3-pyridinyl] boric acid;(5-methyl-6-((2-oxo-2-phenylethyl)amino)pyridin-3-yl)boronic acid;Boronic acid, [6-(benzoylmethylamino)-5-methyl-3-pyridinyl]- (9CI);(5-Methyl-6-(N-methylbenzamido)pyridin-3-yl)boronic acid - [M90189]
- CBNumber:
- CB23370678
- Summenformel:
- C14H15BN2O3
- Molgewicht:
- 270.09
- MOL-Datei:
- 446299-81-6.mol
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[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid Eigenschaften
- Siedepunkt:
- 513.7±60.0 °C(Predicted)
- Dichte
- 1.27±0.1 g/cm3(Predicted)
- Dampfdruck
- 0Pa at 25℃
- storage temp.
- Store at room temperature
- pka
- 4.12±0.18(Predicted)
- Aggregatzustand
- Solid:particulate/powder
- Aussehen
- Off-white to yellow Solid
- InChI
- InChI=1S/C14H15BN2O3/c1-10-8-12(15(19)20)9-16-13(10)17(2)14(18)11-6-4-3-5-7-11/h3-9,19-20H,1-2H3
- InChIKey
- GQPKXFCXPPHXQJ-UHFFFAOYSA-N
- SMILES
- C1=NC(N(C(=O)C2=CC=CC=C2)C)=C(C)C=C1B(O)O
- LogP
- 2.87
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H411 |
Giftig für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 2 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P272 |
Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P321 |
Besondere Behandlung |
| P333+P313 |
Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthese
Under a nitrogen atmosphere, N-(5-bromo-3-methyl-2-pyridinyl)-N-methylbenzamide 30.0 g was dissolved in 150 mL of tetrahydrofuran, triisopropyl borate 22.0 g was added. The reaction mixture was colled to-60 .DEGREE CELSIUS., n-butyl lithium (1.56 mol/L n-hexane solution) 69 mL was added dropwise required to between 20 minutes, and the mixture was stirred for 15 minutes at the same temperature.After raising the temperature of the reaction mixture at-20 .DEGREE CELSIUS., 390 mL of water was added dropwise, it was stirred for 30 min at room temperature,the aqueous layer was separated. The aqueous layer was fractionated and HCl 1 mol/L was added to adjust the pH at 4.5,the precipitate was collected by filtration, 6-[benzoyl(methyl)amino]-5-methyl-3-pyridinylboric acid 18.5 g was obtained as colorless solid.
[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 84)Lieferanten
- Ozenoxacin Impurity 7
- (S) - 6-chloro-3,4-dihydro-2h-thieno [3,2-e] - 1,2-thiazine-4-alcohol 1,1-dioxide
- （ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate），[6-[benzoyl(methyl)amino]-5-methyl-3- pyridyl]boronic acid
- [6- [benzoyl (methyl) amino] -5-methyl-3-pyridinyl] boric acid
- Boronic acid, [6-(benzoylmethylamino)-5-methyl-3-pyridinyl]- (9CI)
- 5-Methyl-6-(phenacylamino)pyridin-3-yl]boronic acid
- [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
- (5-methyl-6-(N-methylbenzamido)pyridin-3-yl)boronic acid
- Ozenoxacin Impurity 15
- (5-methyl-6-((2-oxo-2-phenylethyl)amino)pyridin-3-yl)boronic acid
- OzoxacinIntermediateD
- 8-methyl-7-(5-methyl-6-(N-methylbenzamido)pyridin-3-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- (5-Methyl-6-(N-methylbenzamido)pyridin-3-yl)boronic acid - [M90189]
- 446299-81-6
- C14H15BN2O3
- 446299-81-6
