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Mirogabalin

Mirogabalin Struktur
1138245-13-2
CAS-Nr.
1138245-13-2
Englisch Name:
Mirogabalin
Synonyma:
Asapiprant;2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid;DS5565;A200-0700;Milobarin;mirobalin;Miluobalin;Mirogabalin;Mirogabalin HCl;DS5565;A200-0700
CBNumber:
CB23051612
Summenformel:
C12H19NO2
Molgewicht:
209.28
MOL-Datei:
1138245-13-2.mol

Mirogabalin Eigenschaften

Siedepunkt:
357.5±15.0 °C(Predicted)
Dichte
1.104±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF:0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Ethanol:1.25(Max Conc. mg/mL);5.97(Max Conc. mM)
PBS (pH 7.2):0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Water:5.36(Max Conc. mg/mL);25.61(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
4.65±0.10(Predicted)
Farbe
Light yellow to light brown
InChI
InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1
InChIKey
FTBQORVNHOIASH-CKYFFXLPSA-N
SMILES
[C@]12([H])[C@]([H])([C@@](CN)(CC(O)=O)C1)C=C(CC)C2
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Mirogabalin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Mirogabalin is a calcium channel blocker with analgesic effects. It binds to the α2δ-1 and α2δ-2 subunits of voltage-dependent Ca2+ channels. Mirogabalin has potent and sustained analgesic effects (ED50 = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ; ). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg), at its effective dose. Formulations containing mirogabalin are in clinical trials for diabetic peripheral neuropathic pain.

Verwenden

Mirogabalin is a two alpha2delta ligand which is investigated for the treatment of peripheral neuropathic pain, postherpetic neuralgia and fibromyalgia, showing promising results in patients with diabetic peripheral neuropathy.

Trademarks

Mirogabalin (brand name Tarlige; developmental code name DS-5565) is a gabapentinoid medication developed by Daiichi Sankyo.

Mirogabalin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

tert-butyl 2-((1R,5S,6S)-6-(((tert-butoxycarbonyl)amino)methyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetate Hydrogenchlorid N,N-Diethylethanamin Ethylacetat Dichlormethan

Downstream Produkte

Mirogabalin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 224)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Beijing Hope Pharmaceutical Co., Ltd.
+86-010-67886402 +8613611125266
 market@hopelife.cn China 72 58
Cangzhou Kangrui Pharma Tech Co. Ltd., 		+86-18632776803 +86-13833998158
 cangzhoukangrui@126.com China 751 58
Hebei Junhua Import and Export Co., LTD 		+86-18503288844
junhua1@hb-junhua.com China 957 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19552 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656
 1059@dideu.com China 3178 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677
 faithe@yan-xi.com China 5853 58
TargetMol Chemicals Inc. 		+17819995354
 marketing@targetmol.com United States 32368 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551
sales@afinechem.com China 15222 58
  • Mirogabalin
  • [(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid
  • A200-0700
  • DS5565;A200-0700
  • 2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid
  • MIROGABALIN; DS-5565
  • DS 5565;DS-5565;DS5565
  • Bicyclo[3.2.0]hept-3-ene-6-acetic acid, 6-(aminomethyl)-3-ethyl-, (1R,5S,6S)-
  • Miluobalin
  • 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid
  • Asapiprant
  • DS5565
  • Mirogabalin HCl
  • Milobarin
  • mirobalin
  • Mirogabalin free base
  • Mirogabalin Impurity
  • Mirogabalin base
  • 1138245-13-2
  • API
  • 1138245-13-2
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