COP-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Copaxone was launched in Israel and the US for treatment of relapsingremitting multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed by deprotection. Structurally, the random polymer, with a residue molar ratio of 6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it immunomodulating and immunosuppressive activity (antigen specific so not a general immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR) molecules which results both in competition with myelin antigens for T-cell activation and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific interaction gives rise to a reduced probability of long-term damage to the immune system. The competition with MBP and other myelin-associated antigens inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates and is non-species specific. It resulted in a 29% reduction in relapse rate and is most effective in patients with less accumulated neurologic disability.

Originator

Yeda (Israel)

Trademarks

Copaxone

COP-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

COP-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Protheragen-ING	+16313385890	info@protheragen-ing.com	United States	3868	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
DONBOO AMINO ACID COMPANY	+8618051385538	donboo@donboo.com	China	9363	58
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9980	55
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
Guangzhou Yunmen Biotechnology Co., Ltd	18902340975/189023400307; 18902340307;	3356812514@qq.com;	China	9249	58
Nanjing Yuanpeptide Biotech Co.，Ltd.	18168071971	support@yuan-peptide.com	China	2983	58
Jiangxi ravel Biotechnology Co.,Ltd	185-0276-2003 18502762003;	435918333@qq.com	China	2275	58
HUBEI HICKS BIOCHEMICAL CO.,LTD	18696113233	15927219311@163.com	China	1652	58
Hubei Hicks Biochemical Co., Ltd	17362916295; 17362916295	w17362916295@163.com	China	3987	58

28704-27-0()Verwandte Suche:

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• [L-ALA, L-GLU, L-LYS HBR, L-TYR]N
• COP-1
• POLY(ALA, GLU, LYS, TYR) HYDROBROMIDE
• (t,g)-a-l
• poly(ala
• POLY(ALA, GLU, LYS, TYR) 6:2:5:1*HYDROBR OMIDE MOL.
• Copaxone
• (l-ala, l-glu, l-lys, l-tyr)n ·hbr
• poly(ala, glu, lys, tyr) 6:2:5:1 hydrobromide
• poly(alanine-glutamic acid-lysine-tyrosine)
• COP-1, (L-Ala, L-Glu, L-Lys, L-Tyr)n HBr
• Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
• 28704-27-0
• C3H5NOnH2O
• Polyamino Acids
• Random Copolymers
• Biochemicals and Reagents
• Amino Acids and Peptides
• BioChemical