午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

Remdesivir N-2

Remdesivir N-2 Struktur
1191237-80-5
CAS-Nr.
1191237-80-5
Englisch Name:
Remdesivir N-2
Synonyma:
GS-5;Remdesivir-015;remdesivir N-2;NSJ-Remdesivir-RS009;Redesivir Impurity 8;Remdesivir Impurity 7;Remdesivir Intermediate 4;Remdesivir Intermediate 2;Remdesivir Related Compound 7;Remdesivir No. 5 Intermediate
CBNumber:
CB15493006
Summenformel:
C15H17N5O4
Molgewicht:
331.33
MOL-Datei:
1191237-80-5.mol

Remdesivir N-2 Eigenschaften

Dichte
1.66±0.1 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
L?slichkeit
DMSO:55.5(Max Conc. mg/mL);167.51(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);15.09(Max Conc. mM)
PBS (pH 7.2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM)
DMF:12.0(Max Conc. mg/mL);36.22(Max Conc. mM)
Aggregatzustand
A solid
pka
14.14±0.10(Predicted)
Farbe
Off-white to light yellow
InChI
InChI=1/C15H17N5O4/c1-14(2)23-11-9(5-21)22-15(6-16,12(11)24-14)10-4-3-8-13(17)18-7-19-20(8)10/h3-4,7,9,11-12,21H,5H2,1-2H3,(H2,17,18,19)/t9-,11-,12-,15+/s3
InChIKey
IJCOKJGMVJGKBB-ULVJVTQWNA-N
SMILES
C([C@@]1(C2=CC=C3C(=NC=NN23)N)O[C@H](CO)[C@@]2([H])OC(C)(C)O[C@@]12[H])#N |&1:1,13,16,23,r|
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Remdesivir N-2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Remdesivir N-2 can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in the research and development and chemical production of Remdesivir.

Synthese

Synthesis_1191237-80-5
5.62g of compound GS-441524 was dissolved in 30mL of acetone, 11.50mL of 2,2-dimethoxypropane and 1.34mL of sulfuric acid were added, stirred at 45??C for half an hour, cooled to 25??C, and the organic solvent was removed by rotary evaporation. It was extracted with 100 mL of ethyl acetate and 100 mL of saturated sodium bicarbonate aqueous solution, and the extraction was repeated three times. The ethyl acetate layers were combined, dried by adding anhydrous sodium sulfate, and filtered to remove sodium sulfate. The organic solvent was removed by rotary evaporation, and column chromatography was performed (eluent: petroleum ether/ethyl acetate (V/V)=1/2) to obtain 6.20 g of compound 5 (white solid, 97% yield).

Remdesivir N-2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

GS-441524 D-Ribofuranose, 1-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,3,5-tris-O-(phenylmethyl)- (3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile Remdesivir impurity2 2,3,5-TRI-O-BENZYL-L-ARABINOFURANOSE 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE Aceton-dimethylacetal

Downstream Produkte

Remdesivir

Remdesivir N-2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 110)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Anhui Ruihan Technology Co., Ltd 		+8617756083858
 daisy@anhuiruihan.com China 973 58
Capot Chemical Co.,Ltd. 		+8613336195806
 sales@capot.com China 29731 60
Chengdu Feibo Pharm Technology Co., Ltd 		+86 028-84641798 15982321820
 abby@arkpharm.com China 10922 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29804 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-15536356810
 1022@dideu.com China 3889 58
Nantong Haigine Pharma Technology Co., Ltd 		0086-513-86266699
CHINA 156 58
Linyi Changqing Chemical Co., LTD 		+86-0532-55729510 +8615853232676
 marketing@echemi.com China 322 58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		21-38751876 +8615000076078
 info@rochipharma.com China 505 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626
 eric@witopchemical.com China 23541 58
Hong Kong Tiansheng New Material Trading Co., Ltd 		+8617320695765
 zxx@hktiansheng.com China 973 58
  • (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
  • Remdesivir Intermediate 4
  • Remdesivir Related Compound 7
  • Remdesivir-015
  • Remdesivir O-desphosphate acetonide impurity
  • (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
  • (3Ar,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-4-carbonitrile
  • Remdesivir No. 5 Intermediate
  • (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydr
  • NSJ-Remdesivir-RS009
  • (3ar, 4R, 6R, 6aR) - 4 - (4-aminopyrrole [1,2-f] [1,2,4] triazine-7-yl) - 6 - (hydroxymethyl) - 2,2-dimethyl-tetrahydrofuran [3,4-d] [1,3] dioxazole-4-nitrile
  • 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE-D-ALTRONONITRILE
  • 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-D-Altrononitrile
  • D-ALTRONONITRILE, 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE
  • (3aR,4R,6R,6aR)-4-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
  • (4R)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
  • Remdesivir Impurity 7
  • remdesivir N-2
  • GS-5
  • D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-
  • 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-
  • D-Altrononitrile,2-C-(4-aminopyrrolo[2,1-f][1,2,4Chemicalbook]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-
  • Remdesivir Intermediate 2
  • Remdesivir Acetonide Nitrile Impurity
  • Remdesivir Impurity 7 (Remdesivir Acetonide Nitrile Impurity)
  • Remdesivir O-desphosphate acetonide
  • Redesivir Impurity 8
  • 1191237-80-5
  • PEG
Copyright 2019 ? ChemicalBook. All rights reserved