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Peficitinib hydrobromide

Peficitinib hydrobromide Struktur
1353219-05-2
CAS-Nr.
1353219-05-2
Englisch Name:
Peficitinib hydrobromide
Synonyma:
Peficitinib Hydrobromid;Peficitinib hydrobromide;Peficitinib hydrobromide (JAN/USAN);anti-4-((5-Hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide;4-(5-Hydroxytricyclo3.3.1.13,7dec-2-yl)amino-1H-pyrrolo2,3-bpyridine-5-carboxamide hydrobromide (1:1) stereoisomer
CBNumber:
CB14848254
Summenformel:
C18H22N4O2. HBr
Molgewicht:
407.31
MOL-Datei:
1353219-05-2.mol

Peficitinib hydrobromide Eigenschaften

InChI
InChI=1S/C18H22N4O2.BrH/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10;/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22);1H
InChIKey
ZUVPMAPXNYGJQC-UHFFFAOYSA-N
SMILES
N(C1C(=CN=C2NC=CC=12)C(=O)N)C1C2CC3CC(O)(C2)CC1C3.Br

Sicherheit

Peficitinib hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden

Mechanism of action

Peficitinib hydrobromide potently inhibits the JAK-STAT pathway and blocks the signaling of pro-inflammatory cytokines such as IL-6 and IFN-γ. It has the strongest inhibitory activity against JAK3 (IC?? = 0.7 nM), while also taking into account other subtypes (JAK1/2/Tyk2 IC?? 3.9–5.0 nM).

Synthese

Synthesis of Peficitinib hydrobromide    Peficitinib hydrobromide synthesis

Peficitinib hydrobromide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Peficitinib hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 35)Lieferanten
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BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368
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TargetMol Chemicals Inc. 		+1-781-999-5354;
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TargetMol Chemicals Inc. 		+17819995354
 marketing@targetmol.com United States 19939 58
Shaanxi Dideu New Materials Co. Ltd 		+86-18192503167
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Shanghai Hope Chem Co., Ltd.， +21-18501659228 18501659228
 info@hope-chem.com China 483 55
NANJING WEDO PHARMATECH CO.,LTD. 15189836218
wedo-chem@huawe.com China 308 58
Nanjing Yikangda Pharmaceutical Technology Co.LTD 18118984557
 753016615@qq.com China 457 58
Tsingxin Biopharmaceutical Co., Ltd 18908011947
 3903467217@qq.com China 135 58
  • Peficitinib hydrobromide (JAN/USAN)
  • Peficitinib hydrobromide
  • 4-(5-Hydroxytricyclo3.3.1.13,7dec-2-yl)amino-1H-pyrrolo2,3-bpyridine-5-carboxamide hydrobromide (1:1) stereoisomer
  • Peficitinib Hydrobromid
  • anti-4-((5-Hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide
  • 1353219-05-2
  • C18H22N4O2HBr
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