Pomalidomide-PEG5-CO2H Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-PEG₅-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG5-CO2H Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pomalidomide-PEG5-CO2H Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22685	58
Henan Alfa Chemical Co., Ltd	+8615838112936	alfa10@alfachem.cn	China	13016	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	sales@bicbiotech.com	China	5994	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068	1924344760@confluore.cn	China	2997	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	25003	65
Mashilabs (Shanghai) Co.,Ltd.	19916721580	mafarm@126.com	China	4546	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80

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• POMALIDOMIDE-PEG 5-CO 2 H
• Pomalidomide-PEG5-CO2H
• Propanoic acid, 3-[[14-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12-tetraoxatetradec-1-yl]oxy]-
• Pomalidomide-PEG5-CO2H >=98%
• Pomalidomide-PEG5-COOH
• Pomalidomide-PEG5-CO2H ISO 9001：2015 REACH
• Pomalidomide 4'-PEG5-acid
• 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
• Thalidomide-NH-PEG5-C2-COOH
• 1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12,15-pentaoxaoctadecan-18-oic Acid
• 1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
• Pomalidomide-PEG₅-CO₂H
• 2139348-63-1
• peg