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Hydroxypioglitazone

Hydroxypioglitazone Struktur
146062-44-4
CAS-Nr.
146062-44-4
Englisch Name:
Hydroxypioglitazone
Synonyma:
Leriglitazone;HYDROXYPIOGLITAZONE;Hydroxypioglitazone M4;Pioglitazone Impurity 4;Pioglitazone Impurity 18;Pioglitazone M4 Metabolite;Pioglitazone, hydroxy M-IV;Hydroxy Pioglitazone (M-IV) ;Hydroxy Pioglitazone Solution, 100ppm;5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY] PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE
CBNumber:
CB1299313
Summenformel:
C19H20N2O4S
Molgewicht:
372.44
MOL-Datei:
146062-44-4.mol

Hydroxypioglitazone Eigenschaften

Schmelzpunkt:
157-1580C
Siedepunkt:
627.6±55.0 °C(Predicted)
Dichte
1.325±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under Inert Atmosphere
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Sonicated)
pka
6.35±0.50(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
Stabilit?t:
Hygroscopic
CAS Datenbank
146062-44-4

Sicherheit

Hydroxypioglitazone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).

Chemische Eigenschaften

Off-White Solid

Verwenden

A metabolite of Pioglitazone (P471000).

Hydroxypioglitazone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Benzaldehyde, 4-[2-[5-[1-(methoxymethoxy)ethyl]-2-pyridinyl]ethoxy]- Ethyl-3-(2-methyl-5-pyridyl)-3-oxopropionat 5-(1-(MethoxyMethoxy)ethyl)-2-Methylpyridine 2-(5-(1-(MethoxyMethoxy)ethyl)pyridin-2-yl)ethanol 5-(4-(2-(5-(1-(MethoxyMethoxy)ethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione 1-(6-Methylpyridin-3-yl)ethan-1-on Methyl 6-methylnicotinate

Downstream Produkte

Hydroxypioglitazone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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146062-44-4()Verwandte Suche:

  • HYDROXYPIOGLITAZONE
  • Hydroxy Pioglitazone (M-IV)
  • 5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY] PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE
  • Pioglitazone, hydroxy M-IV
  • Pioglitazone Impurity 18
  • Hydroxy Pioglitazone Solution, 100ppm
  • Pioglitazone M4 Metabolite
  • Leriglitazone
  • Pioglitazone Impurity 4
  • 2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-
  • Hydroxypioglitazone M4
  • 146062-44-4
  • Sulfur & Selenium Compounds
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
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