Pembrolizumab
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- CAS-Nr.
- 1374853-91-4
- Englisch Name:
- Pembrolizumab
- Synonyma:
- MK-3475;pembrolimumab;Pembrolizumab;Lambrolizumab;Pembrolizumab 25mg/ml;Pembrolizumab (anti-PD-1);Research Grade Pembrolizumab;PEMBROLIMUMAB PD-1 1374853-91-4;Research Grade Pembrolizumab(DHH02202);Pembrolizumab - in storage buffer (ca 25 mg/ml)
- CBNumber:
- CB12744222
- Summenformel:
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
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Pembrolizumab Eigenschaften
- storage temp.
- Store at -80°C
- Aggregatzustand
- Liquid
- Farbe
- Colorless to light yellow
- CAS Datenbank
- 1374853-91-4
Pembrolizumab Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
A recombinant, single-chain, anti-CD19/anti-CD3 bispecific monoclonal antibody with potential immunostimulating and antineoplastic activities.
Mechanism of action
Pembrolizumab is a humanized monoclonal IgG4 kappa antibody directed against human cell surface PD-1 (programmed death receptor-1) on lymphocytes. The PD-1 receptor provides a critical “immune checkpoint,” which helps prevent the immune system from attacking itself. Certain tumors have a high expression of PD-L1(programmed death receptor ligand-1). Other tumor types use adaptive immune resistance, which takes the natural physiology of PD-L1 induction (protection of immune-mediated damage from infections) and adapts it to anti-tumor responses. When PD-L1 engages with PD-1, the T-cell function becomes inhibited; pembrolizumab blocks the PD-1: PDL-1 complex formation, allowing improved T-cell mediated killing[1-2].
Pembrolizumab Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pembrolizumab Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 132)Lieferanten
- Lambrolizumab
- Pembrolizumab
- pembrolimumab
- Pembrolizumab (anti-PD-1)
- PEMBROLIMUMAB PD-1 1374853-91-4
- Pembrolizumab 25mg/ml
- PembrolizumabQ: What is
Pembrolizumab Q: What is the CAS Number of
Pembrolizumab Q: What is the storage condition of
Pembrolizumab Q: What are the applications of
Pembrolizumab
- Research Grade Pembrolizumab(DHH02202)
- MK-3475
- Research Grade Pembrolizumab
- Pembrolizumab - in storage buffer (ca 25 mg/ml)
- 1374853-91-4
