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24(S),25-Epoxycholesterol (not deuterated)

24(S),25-Epoxycholesterol (not deuterated) Struktur
77058-74-3
CAS-Nr.
77058-74-3
Englisch Name:
24(S),25-Epoxycholesterol (not deuterated)
Synonyma:
24(S);24S,25-EpoxyC;25-epoxycholesterol;(24S)-24,25-Epoxycholestero;(24S)-24,25-Epoxycholesterol;5-CHOLESTEN-24(S), 25-EPOXY-3β-OL;(24S)-24,25-Epoxycholest-5-en-3β-ol;Cholest-5-en-3-ol, 24,25-epoxy-, (3β,24S)-;24(S),25-Epoxycholesterol (not deuterated);24(S),25-EPOXYCHOLESTEROL;24(S);25-EPOXYCHOLESTEROL
CBNumber:
CB11121024
Summenformel:
C27H44O2
Molgewicht:
400.64
MOL-Datei:
77058-74-3.mol

24(S),25-Epoxycholesterol (not deuterated) Eigenschaften

Schmelzpunkt:
156-157 °C
Siedepunkt:
496.4±18.0 °C(predicted)
Dichte
1.05
storage temp. 
-20°C
L?slichkeit
Soluble in DMSO (up to 30 mg/ml).
Aggregatzustand
White solid.
pka
15.03±0.70(predicted)
Farbe
White
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

Sicherheit

24(S),25-Epoxycholesterol (not deuterated) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ. It inhibits the conversion of desmosterol to cholesterol by 3β-hydroxysterol Δ24-reductase (DHCR24/Seladin-1) in CHO-7 and SRD-1 cells when used at a concentration of 2.5 μM.

Verwenden

(24S)-24,25-Epoxycholesterol is a derivative of 4β-Hydroxy Cholesterol (H917980), a metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.

Definition

ChEBI: A 3beta-hydroxy steroid that is desmosterol in which the double bond at position 24-25 has been oxidised to the corresponding epoxide (the 24S diastereoisomer). It is an oxysterol agonist of the liver X receptor.

24(S),25-Epoxycholesterol (not deuterated) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


24(S),25-Epoxycholesterol (not deuterated) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 24(S),25-Epoxycholesterol (not deuterated)
  • (24S)-24,25-Epoxycholest-5-en-3β-ol
  • (24S)-24,25-Epoxycholesterol
  • 24S,25-EpoxyC
  • (24S)-24,25-Epoxycholestero
  • 24(S)
  • 24(S),25-EPOXYCHOLESTEROL;24(S);25-EPOXYCHOLESTEROL
  • 25-epoxycholesterol
  • Cholest-5-en-3-ol, 24,25-epoxy-, (3β,24S)-
  • 5-CHOLESTEN-24(S), 25-EPOXY-3β-OL
  • 24(S),25-Epoxycholesterol, Endogenous cholesterol metabolite
  • 77058-74-3
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