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PEPA

PEPA Struktur
141286-78-4
CAS-Nr.
141286-78-4
Englisch Name:
PEPA
Synonyma:
PEPA;PEPA;PEPA, 10 mM in DMSO;PEPA,inhibit,Inhibitor,iGluR,Ionotropic glutamate receptors;2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide;Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-;2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)
CBNumber:
CB0972925
Summenformel:
C16H16F2N2O4S2
Molgewicht:
402.44
MOL-Datei:
141286-78-4.mol

PEPA Eigenschaften

Siedepunkt:
617.6±65.0 °C(Predicted)
Dichte
1.47±0.1 g/cm3(Predicted)
storage temp. 
protect from light
L?slichkeit
DMSO: >20mg/mL
Aggregatzustand
solid
pka
10.44±0.40(Predicted)
Farbe
white
InChI
InChI=1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)
InChIKey
GTACSIONMHMRPD-UHFFFAOYSA-N
SMILES
C(N)(=O)COC1=C(F)C=C(SCCNS(C2=CC=CC=C2)(=O)=O)C=C1F

Sicherheit

WGK Germany  3

PEPA Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PEPA is a positive allosteric modulator (PAM) of AMPA receptors. It selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits glutamate receptor 3 (GluR3) and GluR4 over the flip isoforms of these subunits at 200 μM. PEPA (10 mg/kg) decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, in a rat model of memory impairment induced by middle cerebral artery occlusion (MCAO). It decreases freezing time in a contextual fear freezing paradigm in mice when administered at a dose of 30 mg/kg.

Verwenden

PEPA is an allosteric potentiator of AMPA desensitization.

Biologische Aktivit?t

Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.

Biochem/physiol Actions

2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

PEPA Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PEPA Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 69)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32376 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30230 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471
sales@sarms4muscle.com China 10473 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+8618829768577
gao490372054@gamil.com China 1249 58
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 38838 58
Henan Allgreen Chemical Co.,LTD
+86-37155567971 +86-13633837469
info@allgreenchem.com China 5997 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific

tp@aladdinsci.com United States 52924 58

141286-78-4()Verwandte Suche:


  • PEPA
  • 2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide
  • 2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)
  • PEPA,inhibit,Inhibitor,iGluR,Ionotropic glutamate receptors
  • Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-
  • PEPA, 10 mM in DMSO
  • PEPA
  • 141286-78-4
  • C16H16N2O4S2F2
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