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5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Struktur
493028-20-9
CAS-Nr.
493028-20-9
Englisch Name:
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
Synonyma:
CBFβInhibitor;CBFβ Inhibitor;TIMTEC-BB SBB011699;Runx1-CBFβ interaction inhibitor 1;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
CBNumber:
CB0412427
Summenformel:
C12H14N2OS
Molgewicht:
234.32
MOL-Datei:
Mol file

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Eigenschaften

Siedepunkt:
421.6±40.0 °C(Predicted)
Dichte
1.192±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
L?slichkeit
DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
Aggregatzustand
Tan solid
pka
5.00±0.10(Predicted)

Sicherheit

Kennzeichnung gef?hrlicher Xi
HazardClass  IRRITANT

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

Verwenden

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 41)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+17819995354
marketing@targetmol.com United States 32375 58
Aladdin Scientific

tp@aladdinsci.com United States 52924 58
BOC Sciences 1-631-485-4226; 16314854226
info@bocsci.com United States 12952 65
BOC Sciences 16314854226
info@bocsci.com United States 9923 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9803 58
Changzhou Hopschain Chemical Co.,Ltd. 0519-85528066 13775048983
sales@hopschem.com China 31553 55
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8140 58
Shandong Mingde Biotechnology Co., Ltd 18560864701
m15553348166@163.com China 4702 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24982 58

  • TIMTEC-BB SBB011699
  • 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
  • CBFβ Inhibitor
  • 5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
  • CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem
  • 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-
  • Runx1-CBFβ interaction inhibitor 1
  • CBFβInhibitor
  • 493028-20-9
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