5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion
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- CAS-Nr.
- 532-11-6
- Bezeichnung:
- 5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion
- Englisch Name:
- Anethole trithione
- Synonyma:
- Sulfarlem;AnetholTrithione;Trithio;Heporal;Mucinol;skf1717;Sulfogal;Felviten;SKF 1717;Sufralem
- CBNumber:
- CB0168937
- Summenformel:
- C10H8OS3
- Molgewicht:
- 240.36
- MOL-Datei:
- 532-11-6.mol
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5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion Eigenschaften
- Schmelzpunkt:
- 111°
- Siedepunkt:
- 353.09°C (rough estimate)
- Dichte
- 1.4406 (rough estimate)
- Brechungsindex
- 1.5080 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform[soluble in]
- L?slichkeit
- soluble in Chloroform
- Aggregatzustand
- powder to crystal
- Farbe
- Orange-colored prisms from butyl acetate
- Geruch (Odor)
- very bitter taste
- InChI
- InChI=1S/C10H8OS3/c1-11-8-4-2-7(3-5-8)9-6-10(12)14-13-9/h2-6H,1H3
- InChIKey
- KYLIZBIRMBGUOP-UHFFFAOYSA-N
- SMILES
- S1C(C2=CC=C(OC)C=C2)=CC(=S)S1
- CAS Datenbank
- 532-11-6(CAS DataBase Reference)
- NIST chemische Informationen
- 3H-1,2-Dithiole-3-thione, 5-(4-methoxyphenyl)-(532-11-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| HS Code |
2934.99.3000 |
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| Toxizit?t |
LD50 orl-mus: 3850 mg/kg NIIRDN 6,25,82 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anethole trithione is a choleretic drug that can be effective in the treatment of dry mouth, including drug-induced xerostomia. Research suggests that Anethole trithione may exert its therapeutic effects by acting on the alpha-CGRP nerves in the salivary glands, which in turn promotes salivary secretion
[1-2].
synthetische
Anethole trithione can be obtained by the cyclization of anethole and sulfur. Add aniseed oil and dimethylformamide to the reaction tank, stir, and then add sulfur powder. Heat to 146–150 °C, and maintain the reaction for 1.5 hours. At the end of the reaction, cool to 80 °C, recover dimethylformamide under reduced pressure, then cool the reaction mixture to 66 °C. Add xylene and activated carbon, heat to 108 °C, and hold for half an hour before hot filtration. Cool the filtrate to 0 °C to crystallize, then filter and wash with water to obtain the crude product. After refining with xylene or butyl acetate, the final product of anethole trithione is obtained. The yield is 40%.
Pharmakokinetik
Anethole trithione (ATT) appears to have a broad range of unique functions, from increasing salivary secretion to help treat xerostomia, to demonstrating an ability to inhibit carcinogenesis by increasing the activity of electrophile detoxification enzymes, and even being used as an adjunctive therapy for cholecystitis, gallstone, indigestion, and acute/chronic hepatitis and is marketed in certain countries like France, Germany, and China. Unfortunately, many of the specific mechanisms of action to these activities have yet to be formally elucidated, which means that while studies are ongoing, ATT itself is not necessarily formally indicated for many of these aforementioned functions at this time and is only used in limited regions around the world.
Sicherheitsprofil
Poison by intramuscular route.Moderately toxic by ingestion and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of SOx.
5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 331)Lieferanten
532-11-6(5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion)Verwandte Suche:
- Anetholi Trithionum
- 5-(4-methoxyphenyl)dithiole-3-thione
- (E)-O-4-(prop-1-enyl)-5,6-dithioxocyclohexa-1,3-dienyl methanethioate
- 4-(prop-1-en-1-yl)-5,6-disulfanylidenecyclohexa-1,3-dien-1-yl carbothioate
- Anethol trithione ,5-(4-Methoxyphenyl)-1,2-dithiole-3-thione
- Anethali Trithinum
- ANETHOLE TRITHIONE
- 5-(4-methoxyphenyl)-3h-1,2-dithiole-3-thione
- 5-(4-methoxyphenyl)-1,2-dithiole-3-thione
- 3-(p-anisy)trithione
- 3-(p-Methoxyphenyl)trithione
- 3-(p-Methoxyphenyl)-trithione
- Sulfogal
- Sulfralem
- Tiopropen
- Tiotrifar
- Trithio
- Trithio-(p-methoxyphenyl)propene
- Trithioanethole
- 3H-1,2-Dithiole-3-thione, 5-(p-methoxyphenyl)-
- Felviten
- Heporal
- Mucinol
- SKF 1717
- skf1717
- Sufralem
- 5-(4-methoxyphenyl)-3h-2-dithiole-3-thione
- 5-(p-Methoxyphenyl)-1,2-dithiocyclopenten-3-thione
- 5-(p-Methoxyphenyl)-3H-1,2-dithiole-3-thione
- 5-(p-methoxyphenyl)-3h-2-dithiole-3-thione
- TIANFU-CHEM - Anethole trithione
- Anethole trithione CAS 532-11-6
- Anethole trithione USP/EP/BP
- 3H-1,2-Dithiole-3-thione, 5-(4-methoxyphenyl)-
- Anethol Trithione,Felviten
- methanethioic acid O-[4-prop-1-enyl-2,3-bis(sulfanylidene)cyclohexyl] ester
- Sulfarlem
- AnetholTrithione
- 34S3]-Anethole trithione
- Anethole trithione, 10 mM in DMSO
- Anise trisulfide/Galveta
- 532-11-6
- 532-11-2
- 523-11-6
- C10H8OS3
