98453-60-2

基本信息
6-溴-4,4-二甲基-3,4-二氫萘-1(2H)-酮
6-溴-4,4-二甲基-3,4-二氫-2H-萘-1-酮
6-Bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one
6-Bromo-3,4-dihydro-4,4-dimethylnaphthalen-1(2H)-one
6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one
1(2H)-Naphthalenone, 6-bromo-3,4-dihydro-4,4-dimethyl-
6-bromo-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one
常見問題列表

98453-58-8

98453-60-2
以7-溴-1,1-二甲基-1,2,3,4-四氫萘(化合物2,1.1g,4.62mmol)為原料,在10mL二氯甲烷中溶解。向該溶液中加入氧化鉻(VI)(72mg,0.46mmol)和5mL叔丁基過氧化氫溶液(TBHP)。反應(yīng)混合物在室溫下攪拌8小時。反應(yīng)完成后,將混合物用20mL水稀釋,隨后用乙醚(3×10mL)萃取。合并的有機相用鹽水(10mL)洗滌,無水硫酸鎂干燥,減壓濃縮除去溶劑。粗產(chǎn)物通過快速色譜法(洗脫劑比例為90:10的己烷/乙酸乙酯)純化,得到6-溴-4,4-二甲基-3,4-二氫萘-1(2H)-酮(920mg,產(chǎn)率79%)為白色固體。產(chǎn)物經(jīng)1H NMR(CDCl3, 300MHz)表征:δ7.87(d, J = 8.1Hz, 1H),7.54(d, J = 2.1Hz, 1H),7.42(dd, J = 2.1, 8.1Hz, 1H),2.70(dd, J = 6.3, 7.5Hz, 2H),2.01(dd, J = 6.3, 7.5Hz, 2H),1.38(s, 6H)。
參考文獻:
[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4345 - 4359
[2] Patent: WO2005/66115, 2005, A2. Location in patent: Page/Page column 19; 21
[3] Patent: US2005/148590, 2005, A1. Location in patent: Page/Page column 23; 24
[4] Tetrahedron, 1985, vol. 41, # 8, p. 1509 - 1516
[5] Patent: WO2004/46096, 2004, A2. Location in patent: Page 24