85031-59-0

基本信息
雙氫青蒿酸
雙氫青蒿素酸
二氫青蒿酸對(duì)照品
二氫青蒿酸標(biāo)準(zhǔn)品
Dihydroqinghao acid
Dihydroarteannuic acid
Dihydro-Artmisinic Acid
DihydroarteMisinic acid
(2R)-dihydroartemisinic acid
DihydroarteMisinic acid USP/EP/BP
1-Naphthaleneacetic acid, 1,2,3,4,4a,5,6,8a-octahydro-α,4,7-trimethyl-, (αR,1R,4R,4aS,8aS)-
2-(4,7-dimethyl-(1α-H),2,3,(4β-H),(4aα-H),5,6,(8aα-H)-octahydronaphthalen-1-yl)propionic acid
(alphaR,1R,4R,4aS,8aS)-1,2,3,4,4a,5,6,8a-Octahydro-alpha,4,7-trimethyl-1-naphthaleneacetic acid
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表

80286-58-4

85031-59-0
以2-((1R,4R,4aS,8aR)-4,7-二甲基-1,2,3,4,4a,5,6,8a-八氫萘-1-基)丙烯酸為原料合成(R)-2-((1R,4R,4aS,8aS)-4,7-二甲基-1,2,3,4,4a,5,6,8a-八氫萘-1-基)丙酸的一般步驟如下:將100克(0.43摩爾)2-((1R,4R,4aS,8aR)-4,7-二甲基-1,2,3,4,4a,5,6,8a-八氫萘-1-基)丙烯酸溶于800毫升氯仿中。在室溫下,以1.5克鈀碳作為催化劑,在氫氣壓力為1巴的條件下反應(yīng)過(guò)夜。反應(yīng)完成后,通過(guò)硅藻土過(guò)濾反應(yīng)混合物,并用氯仿洗滌濾餅。最后,減壓蒸餾回收溶劑,得到固體產(chǎn)物(R)-2-((1R,4R,4aS,8aS)-4,7-二甲基-1,2,3,4,4a,5,6,8a-八氫萘-1-基)丙酸99克(0.42摩爾),收率為98%。
參考文獻(xiàn):
[1] Journal of Organic Chemistry, 1986, vol. 51, # 26, p. 5417 - 5419
[2] Organic Letters, 2016, vol. 18, # 9, p. 2122 - 2125
[3] Patent: CN107793429, 2018, A. Location in patent: Sheet 0022; 0023; 0027; 0031
[4] Patent: WO2011/30223, 2011, A2. Location in patent: Page/Page column 17; 18
[5] Patent: EP2660234, 2013, A1. Location in patent: Paragraph 0039