74844-91-0
74844-91-0 結(jié)構(gòu)式
基本信息
N-BOC-反式-4-羥基-L-脯氨酸甲酯
N-叔丁氧羰基-反式-4-羥基-L-脯氨酸甲酯
(2S,4R)-N-BOC-4-羥基-2-吡咯啉甲酸甲酯
N-叔丁氧羰基-L-脯氨酸甲酯
N-BOC-反式-L-羥脯氨酸甲酯
(2S,4R)-1-(TERT-BUTOXYCARBONYL)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE
(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER
BOC-HYDROXYPROLINE-OME
BOC-HYP-OME
BOC-L-4-HYDROXYPROLINE METHYL ESTER
BOC-L-4-TRANS-HYDROXYPROLINE METHYL ESTER
BOC-L-HYDROXYPROLINE METHYL ESTER
BOC-L-T-4-HYDROXYPROLINE METHYL ESTER
BOC-TRANS-4-HYDROXY-L-PROLINE METHYL ESTER
METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE
N-ALPHA-T-BUTOXYCARBONYL-L-HYDROXYPROLINE METHYL ESTER
N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER
N-BOC-L-TRANS-4-HYDROXY-PROLINE METHYL ESTER
N-BOC-TRANS-4-HYDROXYL-L-PROLINE METHYL ESTER
N-BOC-TRANS-4-HYDROXY-L-PROLINE METHYL ESTER
N-T-BOC-TRANS-4-HYDROXY-L-PROLINE METHYL ESTER
N-(TERT-BUTOXYCARBONYL)-TRANS-HYDROXYL-L-PROLINE METHYL ESTER
N-BOC-TRANS-4-HYDROXY-L-PROLINE METHYL &
N-Boc-trans-hydro-L-prolinemethylester
物理化學性質(zhì)
安全數(shù)據(jù)
制備方法
24424-99-5
40216-83-9
74844-91-0
以二碳酸二叔丁酯和反式-4-羥基-L-脯氨酸甲酯鹽酸鹽為原料合成N-Boc-反式-4-羥基-L-脯氨酸甲酯的一般步驟如下：將步驟I中得到的反式-4-羥基-L-脯氨酸甲酯鹽酸鹽（14.5g，0.1mol）懸浮于CH2Cl2（400mL）中，冷卻至0℃，攪拌下依次加入Et3N（28mL，0.2mol）、DMAP（0.61g，5mmol）和Boc酐（27.5mL，0.12mol）。反應(yīng)混合物逐漸升溫至室溫并繼續(xù)攪拌2小時。反應(yīng)完成后，減壓濃縮除去溶劑，向殘留固體中加入乙醚，過濾收集固體并用乙醚充分洗滌。合并濾液，減壓濃縮。將殘余物溶解于CH2Cl2中，依次用飽和NaHCO3水溶液和飽和NaCl水溶液洗滌，有機相用無水Na2SO4干燥。減壓蒸除溶劑，得到淺黃色油狀物，經(jīng)高真空處理固化。所得固體用己烷多次研磨，高真空干燥，得到1-叔丁基-2-甲基（2S，4R）-4-羥基吡咯烷-1,2-二甲酸酯，為白色固體（24.5g，收率100%）。產(chǎn)物表征數(shù)據(jù)如下：(M+1) 245; 1H NMR (CDCl3, 300MHz) δ 4.54-4.37 (m, 2H), 3.75 (s, 3H), 3.70-3.40 (m, 2H), 2.48-2.21 (m, 2H), 2.13-2.0 (m, 1H), 1.46 (s, 3H), 1.41 (s, 6H)。
參考文獻：
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 22, p. 5699 - 5702
[2] Patent: WO2007/113634, 2007, A1. Location in patent: Page/Page column 60-61
[3] Tetrahedron Asymmetry, 2009, vol. 20, # 12, p. 1433 - 1436
[4] Journal of Chemical Research, 2009, # 11, p. 668 - 670
[5] Tetrahedron Letters, 2012, vol. 53, # 30, p. 3847 - 3849
常見問題列表
N-Boc-反式-4-羥基-L-脯氨酸甲酯為羧酸酯類有機物，可用于合成基于Met的For-Met-Leu-Phe-OMe（fMLF-OMe）類似物，殘基被4-氨基脯氨酸支架置換。
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | H59027 | N-Boc-反-4-羥基-L-脯氨酸甲基酯 97% N-Boc-trans-4-hydroxy-L-proline methyl ester, 97% | 74844-91-0 | 5g | 199元 |
| 2025/05/22 | H59027 | N-Boc-反-4-羥基-L-脯氨酸甲基酯 97% N-Boc-trans-4-hydroxy-L-proline methyl ester, 97% | 74844-91-0 | 1g | 204元 |
| 2025/05/22 | 37625 | N-Boc-反-4-羥基-L-脯氨酸甲基酯 N-BOC-trans-4-Hydroxy-L-proline methyl ester, 97%, Thermo Scientific Chemicals | 74844-91-0 | 5g | 883元 |