66346-87-0

基本信息
6-氯-5-甲基噠嗪-3-胺
3-氨基-5-甲基-6-氯噠嗪
5-甲基-6-氯-3-氨基噠嗪
3-氯-4-甲基-6-氨基噠嗪
6-dihydropyridazin-3-aMine
6-Chloro-5-methyl-3-pyridazinamine
6-chloro-5-Methylpyridazin-3-aMine
3-PyridazinaMine,6-chloro-5-Methyl-
6-Amino-3-chloro-4-methylpyridazine
(6-Chloro-5-methylpyridazin-3-yl)amine
Pyridazine, 6-amino-3-chloro-4-methyl-(6CI,7CI)
6-chloro-5-Methyl-3,6-dihydropyridazin-3-aMine ISO 9001:2015 REACH
物理化學(xué)性質(zhì)
制備方法

19064-64-3

66346-87-0

64068-00-4
以3,6-二氯-4-甲基噠嗪為原料合成3-氨基-5-甲基-6-氯噠嗪和3-氨基-4-甲基-6-氯噠嗪的一般步驟如下[Linholter, S., et al., Acta Chem. Scand. 15:1660-1666 (1961)]:向3,6-二氯-4-甲基噠嗪(200 mg)的乙醇(3 mL)溶液中加入液氨(3 mL)。將反應(yīng)混合物置于密封管中,于120℃下加熱12小時。反應(yīng)完成后,冷卻至室溫,蒸發(fā)除去甲醇和氨。殘余物通過快速色譜法(洗脫劑:乙酸乙酯)進(jìn)行純化,得到153 mg的3-氨基-5-甲基-6-氯噠嗪和3-氨基-4-甲基-6-氯噠嗪(比例為1:1)的混合物,收率為87%。該混合物無需進(jìn)一步分離即可直接用于后續(xù)實驗。
參考文獻(xiàn):
[1] Patent: WO2007/33080, 2007, A2. Location in patent: Page/Page column 26; 37
[2] Patent: WO2014/72261, 2014, A1. Location in patent: Page/Page column 48
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
[4] Australian Journal of Chemistry, 1986, vol. 39, # 11, p. 1803 - 1809
[5] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233