578-74-5
578-74-5 結構式
基本信息
芹菜苷配基-7-O-葡糖苷
芹菜素-7-葡萄糖苷
芹菜甙元(芹菜素)-7-葡萄糖甙
芹菜甙元(芹菜素)-7-O-葡萄糖甙
芹菜素-7- O -葡萄糖苷
大波斯菊苷
芹菜甙元-7- 葡萄糖甙
芹菜甙元-7- O-葡萄糖甙
芹甙元-7-葡萄糖苷
COSMETIN
COSMOSIIN
APIGETRIN
Cosemetin
Cosmosioside
APIGENIN-7-GLUCOSIDE
Apigetrin, Cosmosiin
APIGENIN-7-O-GLUCOSIDE
Apigenin 7-β-D-glucoside
Apigenin 7-b-D-glucoside
Apigenin-7-O-β-D-glucoside
Apigenin 7-beta-D-glucoside
APIGENIN-7-O-GLUCOSIDE hplc
7-o-(beta-D-Glucosyl)apigenin
APIGENIN-7-O-GLUCOSIDE WITH HPLC
Apigenin-7-O-β-D-glucopyranoside
Apigenin, 7-beta-D-glucopyranoside
APIGENIN-7-GLUCOSIDE (COSMOSIIN)(P)
APIGENIN-7-O-GLUCOSIDE (COSMOSIIN)(P)
APIGENIN-7-O-GLUCOSIDE (COSMOSIIN)(SH)
Apigenin 7-glucoside SynonyMs:Apigetrin
7-O-BETA-D-GLUCOPYRANOSYLOXY-4',5-DIHYDROXYFLAVONE
4H-1-Benzopyran-4-one,7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)
4H-1-Benzopyran-4-one,7-(b-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-
7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 7- (.beta.-D-glucopyranosyloxy)-5-hydroxy-2-(4- hydroxyphenyl)-
4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)- (9ci)
物理化學性質
制備方法
![4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-7-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-](/CAS/20210305/GIF/119249-30-8.gif)
119249-30-8
578-74-5
在攪拌條件下，將化合物1（CAS: 119249-30-8，150 mg，0.25 mmol）溶于甲醇（20 mL）和30%氨水（5 mL）的混合溶液中。反應混合物在室溫下持續(xù)攪拌12小時。反應完成后，通過減壓蒸餾除去溶劑。所得殘余物通過硅膠柱色譜法進行純化，采用乙酸乙酯/甲醇（3:1，v/v）作為洗脫劑，得到目標產物5-羥基-2-(4-羥基苯基)-7-(((2S,3R,4S,5S,6R)-3,4,5-三羥基-6-(羥甲基)四氫-2H-吡喃-2-基)氧基)-4H-苯并吡喃-4-酮，為黃色固體（78 mg，收率72%）。產物的熔點為234-236°C（文獻值：238-239°C）。紅外光譜（KBr壓片，cm^-1）顯示特征吸收峰：3440, 2918, 1615, 1563, 1452, 1346, 1273, 1245, 1146, 1103, 1072, 1024, 895。核磁共振氫譜（400 MHz, DMSO-d6）δ：12.97（s, 1H, OH-5），10.48（s, 1H, OH-4'），7.96（d, J = 8.8 Hz, 2H, H-2', H-6'），6.94（d, J = 8.8 Hz, 2H, H-3', H-5'），6.87（s, 1H, H-3），6.83（d, J = 1.6 Hz, 1H, H-8），6.45（d, J = 1.6 Hz, 1H, H-6），5.42（d, J = 8.0 Hz, 1H, H-1），5.15（s, 1H, OH-2），5.08（s, 1H, OH-3），5.06（s, 1H, OH-4），4.63（s, 1H, OH-6），3.72-3.70（m, 1H, H-2），3.49-3.18（m, 5H, H-3,4,5,6）。核磁共振碳譜（100 MHz, DMSO-d6）δ：60.6, 69.6, 73.1, 76.5, 77.2, 94.8, 99.6, 99.9, 103.1, 105.4, 116.0, 121.1, 128.6, 156.9, 161.1, 161.4, 163.0, 164.3, 180.1。高分辨質譜（HRMS）計算值[M + Na]+ C21H20O10Na為455.3665，實測值為455.3649。
參考文獻：
[1] Tetrahedron, 2004, vol. 60, # 9, p. 2025 - 2034
[2] Carbohydrate Research, 2012, vol. 357, p. 41 - 46
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | HY-N0578 | 芹甙元-7-葡萄糖苷 Apigenin 7-glucoside | 578-74-5 | 1 mg | 409元 |
| 2025/05/22 | HY-N0578 | 芹甙元-7-葡萄糖苷 Apigenin 7-glucoside | 578-74-5 | 10 mM * 1 mLin DMSO | 904元 |
| 2025/05/22 | HY-N0578 | 芹甙元-7-葡萄糖苷 Apigenin 7-glucoside | 578-74-5 | 5mg | 950元 |
常見問題列表
Apigenin 7-glucoside exhibits significant anti-proliferative activity against B16F10 melanoma cells after 24 and 48 h of incubation. Apigenin-7-glucoside provoks an increase of subG0/G1, S and G2/M phase cell proportion with a significant decrease of cell proportion in G0/G1 phases. Apigenin-7-glucoside enhances melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells.
Apigenin 7-glucoside specifically induces the differentiation of CD34
+
cells towards the erythroid lineage and inhibited the myeloid differentiation. Apigenin 7-glucoside has strong antioxidant activity against reactive oxygen species (ROS) in vitro in a concentration-dependent manner.