55750-53-3
55750-53-3 結(jié)構(gòu)式
基本信息
6-馬來酰亞胺基己酸
N-(5-羧基戊基)馬來酰亞胺
6-MALEIMIDOHEXANOIC ACID
EMCA
EPSILON-MALEIMIDOCAPROIC ACID
MCA
N-(5-CARBOXYPENTYL)MALEIMIDE
N-EPSILON-MALEIMIDOCAPROIC ACID
N-MALEOYL-6-AMINO-CAPROIC ACID
6-MALEIMIDOCAPROIC ACID, 98+%
6-Maleinimidocaproicacid
6-(2,5-Dioxo-2H-pyrrol-1(5H)-yl)hexanoic acid
6-MALEIMIDOHEXANOIC ACID DIHYDRATE
6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid
6-Maleimidocaproic acid, N-(5-Carboxypentyl)maleimide, N-Maleoyl-6-aminocaproic acid
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
108-31-6
60-32-2
55750-53-3
向30 mL冰醋酸中加入3.9 g (0.03 mol) 6-氨基己酸和3.5 g (0.036 mol, 1.2當(dāng)量)馬來酸酐。將反應(yīng)混合物在120℃下攪拌4-6小時。反應(yīng)完成后，停止加熱，讓反應(yīng)混合物自然冷卻至室溫。在60℃下減壓濃縮以除去大部分乙酸。將得到的棕黃色粘稠液體倒入水中。然后用乙酸乙酯(20 mL×3)進行萃取，合并有機層。依次用水洗滌有機層，用無水硫酸鈉干燥，過濾，減壓濃縮濾液，得到棕黃色油狀物。向該油狀物中加入50 mL水并攪拌，有白色固體沉淀析出。過濾收集沉淀，并在50℃下真空干燥，得到目標(biāo)產(chǎn)物6-馬來酰亞胺基己酸5.08 g，收率為80%。
參考文獻：
[1] Patent: CN107789630, 2018, A. Location in patent: Paragraph 0061; 0062; 0063
[2] Patent: CN108743968, 2018, A. Location in patent: Paragraph 0004; 0005; 0006
[3] Patent: WO2015/95223, 2015, A2. Location in patent: Page/Page column 67
[4] Patent: WO2016/90050, 2016, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2016/90038, 2016, A1. Location in patent: Page/Page column 123