53267-93-9
53267-93-9 結構式
基本信息
BOC-O-甲基-L-酪氨酸
N-叔丁氧羰基-4-甲氧基-L-苯丙氨酸
BOC-4-METHOXY-PHE-OH
BOC-L-4-METHOXYPHE
BOC-L-TYR(ME)
BOC-L-TYR(ME)-OH
BOC-O-METHYL-L-TYROSINE
BOC-PHE(4-OME)-OH
BOC-P-METHOXY-PHE-OH
BOC-S-TYR(ME)-OH
BOC-TYR(ME)-OH
BOC-TYROSINE(ME)-OH
L-4'-METHOXY-N-BOC-TYROSINE
N-ALPHA-T-BOC-O-METHYL-L-TYROSINE
N-ALPHA-T-BOC-P-METHOXY-L-PHENYLALANINE
N-ALPHA-T-BUTOXYCARBONYL-4-METHOXY-L-PHENYLALANINE
N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-TYROSINE
N-ALPHA-T-BUTOXYCARBONYL-O-METHY-L-TYROSINE
N-ALPHA-TERT-BUTYLOXYCARBONYL-O-METHYL-L-TYROSINE
(S)-2-TERT-BUTOXYCARBONYLAMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID
(S)-N-ALPHA-T-BUTYLOXYCARBONYL-O-METHYL-TYROSINE
物理化學性質
制備方法
94790-24-6
53267-93-9
在0℃下，向(S)-2-((叔丁氧羰基)氨基)-3-(4-甲氧基苯基)丙酸甲酯（498mg，1.61mmol）的THF/MeOH/H2O（3:1:1，5mL）溶液中加入LiOH·H2O（142mg，3.22mmol）。反應混合物在0℃下攪拌1小時后，蒸發(fā)去除有機溶劑。殘余物用15%檸檬酸水溶液處理，調節(jié)pH至3，隨后用乙酸乙酯（35mL）萃取。合并的有機層用鹽水（5mL）洗滌，無水Na2SO4干燥，并真空濃縮。粗產物通過硅膠柱色譜純化（洗脫劑：乙酸乙酯/石油醚=2:1），得到(S)-2-((叔丁氧羰基)氨基)-3-(4-甲氧基苯基)丙酸（466mg，98%），為無色油狀物。1H NMR (300 MHz, CD3OD): δ 7.13 (2H, d, J=8.4 Hz), 6.82 (2H, d, J=8.4 Hz), 4.31-4.29 (1H, m), 3.73 (3H, s), 3.08 (1H, dd, J=13.8, 4.5 Hz), 2.85 (1H, dd, J=13.5, 8.7 Hz), 1.38 (9H, s)。13C NMR (75 MHz, CD3OD): δ 175.42, 159.95, 157.67, 131.27, 130.37, 114.81, 80.50, 56.37, 55.64, 37.86, 28.67。
參考文獻：
[1] Tetrahedron, 2014, vol. 70, # 37, p. 6630 - 6640
[2] Patent: CN107353239, 2017, A. Location in patent: Paragraph 0173; 0174
[3] Patent: CN107468690, 2017, A. Location in patent: Paragraph 0173; 0174
[4] Synthesis, 1984, vol. NO. 7, p. 572 - 574
[5] Journal of Organic Chemistry, 1981, vol. 46, # 9, p. 1944 - 1946