51419-59-1
51419-59-1 結(jié)構(gòu)式
基本信息
(4-甲基苯基)甲烷磺酰氯
4-甲基芐磺酰氯
(4-甲基苯)甲烷磺酰氯
(4-甲苯基)甲烷黃酰氯,TECH,97%
4-METHYLBENZYLSULFONYL CHLORIDE
(4-METHYLPHENYL)METHANESULFONYL CHLORIDE
[(4-METHYLPHENYL)METHYL]SULFONYL CHLORIDE
P-METHYL-ALPHA-TOLUENESULFONYL CHLORIDE
P-TOLYL-METHANESULFONYL CHLORIDE
[(4-methylphenyl)methyl]sulphonyl chloride
4-Methylbenzylsulphonyl chloride, alpha-p-Xylenesulphonyl chloride
ɑ-p-Xylenesulfonyl chloride, 97%
p-Methyl-α-toluenesulfonyl chloride
(4-Methylphenyl)methanesulfonyl chloride, 4-Methylbenzenemethanesulfonyl chloride, p-Methyl-α-toluenesulfonyl chloride, p-Tolylmethanesulfonyl chloride
^a-p-Xylenesulfonyl chloride, 97%
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
940-63-6
51419-59-1
通用方法：將烷基鹵（或硫酸鹽）（5mmol）與硫脲（0.381g，5mmol）在乙醇（5mL）中回流加熱1小時(shí)。反應(yīng)完成后，在真空條件下除去溶劑，并用乙醚（3×5mL）洗滌殘余物，得到相應(yīng)的S-烷基異硫脲鹽，為白色固體，收率接近定量。無(wú)需進(jìn)一步純化，將所得產(chǎn)物轉(zhuǎn)移至配備溫度計(jì)和加料漏斗的三頸圓底燒瓶中，置于冰浴中。隨后加入水（0.45mL）和乙腈（10mL）。在劇烈攪拌下，向混合物中緩慢滴加叔丁基次氯酸鹽（2.86mL）的乙腈（5mL）溶液，控制反應(yīng)溫度在0-20℃范圍內(nèi)。滴加完畢后，繼續(xù)攪拌反應(yīng)混合物30分鐘。反應(yīng)結(jié)束后，在真空條件下除去溶劑，加入乙醚（15mL）溶解殘余物，用水（2×10mL）洗滌有機(jī)相，無(wú)水硫酸鈉干燥，最后在真空下濃縮，得到高純度的4-甲基芐磺酰氯。產(chǎn)物可通過(guò)石油醚-乙酸乙酯混合溶劑重結(jié)晶進(jìn)一步純化。
參考文獻(xiàn)：
[1] Synthesis (Germany), 2015, vol. 47, # 20, p. 3186 - 3190
[2] European Journal of Organic Chemistry, 2012, # 26, p. 5028 - 5037,10
[3] European Journal of Organic Chemistry, 2012, # 26, p. 5028 - 5037
[4] Journal of the American Chemical Society, 1987, vol. 109, # 24, p. 7472 - 7477
[5] Synthesis (Germany), 2013, vol. 45, # 12, p. 1675 - 1682
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | 45484 | 4-甲基芐磺酰氯 4-Methylbenzylsulfonyl chloride, 97%, Thermo Scientific Chemicals | 51419-59-1 | 1g | 962元 |
| 2025/05/22 | 45484 | 4-甲基芐磺酰氯 4-Methylbenzylsulfonyl chloride, 97%, Thermo Scientific Chemicals | 51419-59-1 | 5g | 2577元 |
| 2025/05/22 | XW025141959104 | 對(duì)甲基芐磺酰氯 | 51419-59-1 | 10G | 548元 |