4701-17-1

基本信息
5-溴硫代苯-2-甲醛
5-溴噻吩-2-甲醛
5-溴-2-噻吩甲醛
5-BROMO-2-THIOPHENECARBALDEHYDE
5-BROMO-2-THIOPHENECARBOXALDEHYDE
5-BROMOTHIOPHENE-2-ALDEHYDE
5-BROMO-THIOPHENE-2-CARBALDEHYDE
5-BROMOTHIOPHENE-2-CARBOXALDEHYDE
AKOS BBS-00003268
LABOTEST-BB LT00112291
TIMTEC-BB SBB000294
2-Thiophenecarboxaldehyde, 5-bromo-
5-BROMOTHIOPHENE-2-CARBALDEHYDE 98%
2-BROMO-5-THIOPHENECARBOXALDEHYDE
5-Bromothiophene-2-Aldehyde98%
5-Bromothiophene-2-Aldehyde 98%
2-BROMOTHIOPHENE-5-CARBOXALDEHYDE
5-bromothenaldehyde
5-BROMO-2-THIIOPHENE CARBOXALDEHYDE
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
將95.5g(0.33mol)三溴氧磷加入盛有45g(0.32mol)N-甲基甲酰苯胺和32.6g(0.2mol)2-溴噻吩的反應(yīng)瓶中(通風(fēng)櫥中進(jìn)行)。此時(shí)發(fā)生劇烈反應(yīng),冷卻,以降低溴化氫產(chǎn)生的速度。然后置于蒸汽浴上加熱1h。冷卻后,以乙酸鈉的水溶液中和。水蒸氣蒸餾,餾出物以乙醚萃取,乙醚萃取物用6mol/L鹽酸及5%碳酸氫鈉先后洗滌后,用無(wú)水硫酸鈉干燥。蒸餾,得20.5g5-溴-2-噻吩甲醛,沸點(diǎn)80~83℃(267Pa)。
上下游產(chǎn)品信息
常見(jiàn)問(wèn)題列表

98-03-3

4701-17-1
2.1.1 5-溴-2-噻吩甲醛的合成 在氮?dú)獗Wo(hù)下,將2-噻吩甲醛(6.0 g,53.5 mmol)溶解于無(wú)水氯仿(125 mL)中。隨后,緩慢加入N-溴代琥珀酰亞胺(10.4 g,58.9 mmol),并將反應(yīng)混合物在室溫下攪拌12小時(shí)。反應(yīng)完成后,用氯仿(3 × 50 mL)萃取混合物,合并有機(jī)相并用去離子水(2 × 50 mL)洗滌。有機(jī)層經(jīng)無(wú)水硫酸鈉干燥后,過(guò)濾并減壓濃縮,得到粗產(chǎn)物。粗產(chǎn)物通過(guò)硅膠柱色譜純化,以氯仿為洗脫劑,得到5-溴-2-噻吩甲醛,為無(wú)色油狀物(10.0 g,收率98%)。 1H NMR (400 MHz, CDCl3): δ 7.20 (d, 1H, J = 4.0 Hz), 7.53 (d, 1H, J = 8.0 Hz), 9.79 (s, 1H)。
參考文獻(xiàn):
[1] Physica B: Condensed Matter, 2017, vol. 519, p. 53 - 58
[2] Tetrahedron, 2007, vol. 63, # 37, p. 9188 - 9194
[3] Tetrahedron Letters, 2005, vol. 46, # 12, p. 1989 - 1992
[4] Patent: WO2018/67786, 2018, A1. Location in patent: Page/Page column 134; 135
[5] Journal of the Chemical Society, 1958, p. 1721
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2025/05/22 | A13381 | 5-溴噻酚-2-甲醛, 97% 5-Bromothiophene-2-carboxaldehyde, 97% | 4701-17-1 | 5g | 277元 |
2025/05/22 | A13381 | 5-溴噻酚-2-甲醛, 97% 5-Bromothiophene-2-carboxaldehyde, 97% | 4701-17-1 | 25g | 774元 |
2025/05/22 | A13381 | 5-溴噻酚-2-甲醛, 97% 5-Bromothiophene-2-carboxaldehyde, 97% | 4701-17-1 | 100g | 2078元 |