33125-05-2
33125-05-2 結(jié)構(gòu)式
基本信息
BOC-D-PHG-OH
Boc-D-苯甘氨酸
N-BOC-D-苯基甘氨酸
N-叔丁氧羰基-D-苯甘氨酸
BOC-L-PHENYLGLYCINE
BOC-L-PHG
BOC-L-PHG-OH
BOC-PHENYLGLYCINE
BOC-(PHENYL)GLY-OH
BOC-PHG-OH
N-ALPHA-T-BOC-L-PHENYLGLYCINE
N-ALPHA-T-BUTOXYCARBONYL-T-PHENYLGLYCINE
N-ALPHA-(T-BUTYLOXYCARBONYL)-L-PHENYLGLYCINE
N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PHENYLGLYCINE
N-BOC-L-PHENYLGLYCINE
RARECHEM EM WB 0179
(S)-TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID
Boc-D-Phg-OH~N-(tert-Butoxycarbonyl)-D-phenylglycine
N-tert-Butoxycarbonyl-D-phenylglycine
Boc-D-Phenylglycine
BOC-3-CHLORO-PHENYLGLYCINE
Boc-(R)-2-aminobenzeneacetic acid
N-(tert-Butoxycarbonyl)-D-2-phenylglycine
物理化學(xué)性質(zhì)
制備方法
24424-99-5
875-74-1
33125-05-2
(1) 將 (R)-2-氨基-2-苯基乙酸 (200 g, 1.32 mol) 和碳酸鉀 (218 g, 1.58 mol) 的混合物溶解于水 (2.0 L) 和甲醇 (0.5 L) 的混合溶劑中，冷卻至溫度低于 10°C。緩慢滴加二碳酸二叔丁酯 (288 g, 1.32 mol)，滴加完畢后于室溫下攪拌反應(yīng)過夜。反應(yīng)完成后，用 1 N 鹽酸調(diào)節(jié)反應(yīng)液 pH 至 4-5，隨后用乙酸乙酯 (1.0 L × 3) 進(jìn)行萃取。合并有機(jī)相，用飽和食鹽水 (1.0 L × 1) 洗滌，無水硫酸鈉干燥后減壓濃縮，得到白色固體產(chǎn)物 (315 g)，收率為 95%。
參考文獻(xiàn)：
[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8049 - 8065
[2] Journal of Medicinal Chemistry, 1991, vol. 34, # 3, p. 968 - 978
[3] Tetrahedron Letters, 1995, vol. 36, # 29, p. 5227 - 5230
[4] Patent: CN104592163, 2016, B. Location in patent: Paragraph 0041; 0042
[5] Patent: CN106748892, 2017, A. Location in patent: Paragraph 0051; 0053; 0054; 0055
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | L18540 | N-Boc-D-苯基甘氨酸, 99% N-Boc-D-phenylglycine, 99% | 33125-05-2 | 1g | 222元 |
| 2025/05/22 | L18540 | N-Boc-D-苯基甘氨酸, 99% N-Boc-D-phenylglycine, 99% | 33125-05-2 | 5g | 350元 |
| 2025/05/22 | 43764 | N-Boc-D-苯基甘氨酸 BOC-D-alpha-phenylglycine, 99%, Thermo Scientific Chemicals | 33125-05-2 | 1g | 472元 |