31576-51-9
31576-51-9 結(jié)構(gòu)式
基本信息
氨基-甲基二乙二醇
甲氧基-二聚乙二醇-胺
甲基-二聚乙二醇-氨基
2-(2-甲氧基乙氧基)-乙胺
1-(2-氨基乙氧基)-2-甲氧基乙烷
MPEG2-NH2 分枝單甲氧基 聚乙二醇胺
m-PEG2-amine
NH2-PEG2-OME
MeO-EG(2)-NH2
Methyl-PEG2-amine
2-(2-Methoxyethoxy)ethanamine
2-(2-Methoxyethoxy)ethylamine
mPEG2-NH2
EthanaMine, 2-(2-Methoxyethoxy)-
2-(2-Methoxyethoxy)ethoxy]ethenamine
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
![1H-Isoindole-1,3(2H)-dione, 2-[2-(2-methoxyethoxy)ethyl]-](/CAS/20210305/GIF/179820-15-6.gif)
179820-15-6
31576-51-9
2.2.1.3 2-(2-甲氧基乙氧基)乙胺(2d)的合成 將N-[2-(2-甲氧基乙氧基)乙基]鄰苯二甲酰亞胺(2c)(27 mmol)和一水合肼(43 mmol)在乙醇(30 mL)中的混合物于100℃下回流3小時(shí)。反應(yīng)完成后，將混合物冷卻至室溫，過(guò)濾，并蒸發(fā)濾液。向殘余物中加入丙酮(50 mL)，過(guò)濾沉淀。隨后，將濾液減壓濃縮，得到橙色油狀物2d，產(chǎn)率為62%。 1H NMR (500 MHz, CDCl3): δ 1.83 (s, 1H), 2.00 (s, 1H), 2.15 (s, 1H), 2.87 (t, J = 5.3 Hz, 1H), 3.35-3.39 (m, 2H), 3.41 (t, J = 6.4 Hz, 1H), 3.50 (t, J = 5.3 Hz, 1H), 3.52-3.55 (m, 2H), 3.60 (dd, J = 5.7, 3.3 Hz, 1H), 3.64 (dd, J = 5.6, 3.8 Hz, 1H), 3.73 (t, J = 6.5 Hz, 1H) ppm; HR ESI-MS (in MeOH): m/z [M + H]+ calcd. 120.0973, found 120.1047.
參考文獻(xiàn)：
[1] Journal of Organic Chemistry, 2011, vol. 76, # 6, p. 1683 - 1691
[2] Journal of Organic Chemistry, 2010, vol. 75, # 3, p. 598 - 610
[3] Inorganica Chimica Acta, 2016, vol. 452, p. 159 - 169
[4] Patent: WO2009/109035, 2009, A1. Location in patent: Page/Page column 57-58
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | HY-W008429 | 1-(2-氨基乙氧基)-2-甲氧基乙烷 m-PEG2-Amine | 31576-51-9 | 1 g | 150元 |
| 2025/05/22 | HY-W008429 | 1-(2-氨基乙氧基)-2-甲氧基乙烷 m-PEG2-Amine | 31576-51-9 | 5 g | 301元 |
| 2025/05/22 | HY-W008429 | 1-(2-氨基乙氧基)-2-甲氧基乙烷 m-PEG2-Amine | 31576-51-9 | 10 g | 540元 |
常見問(wèn)題列表
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.