30459-17-7
30459-17-7 結(jié)構(gòu)式
基本信息
三氟甲基苯基哌嗪
1-(4-三氟甲基苯基)哌嗪
1-(4-TRIFLUOROMETHYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE
1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLYL)PIPERAZINE
4-PIPERAZINOBENZOTRIFLUORIDE
N-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE
N-(ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLYL)PIPERAZINE
RARECHEM AH CK 0204
trifluoromethylphenylpiperazine
1-(4-Trifluormethylphenyl)-piperazine
1-(α,α,α-trifluoro-p-tolyl)piperazine
1-[4-(Trifluoromethyl)phenyl]piperazine 97%
1-[4-(Trifluoromethyl)phenyl]piperazine97%
1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE PURUM 98+% (GC)
1-(4-TRIFLUOROMETHYLPHENYL)-PIPERAZINE >98%
1-(4-Trifluoromethyphenyl) piperazine
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
110-85-0
98-56-6
30459-17-7
實(shí)施例4：將4-氯三氟甲苯（18.5 g，100 mmol）和哌嗪（12.9 g，150 mmol）溶解于200 mL三正丁胺中，室溫下通入氮?dú)?5分鐘進(jìn)行脫氣。隨后加入無水叔丁醇鈉（13.5 g，140 mmol），繼續(xù)脫氣10分鐘。在另一容器中，將[2-(2,6-二甲氧基苯基)苯基]二環(huán)己基膦（41 mg，0.1 mmol）與（二亞芐基丙酮）鈀（20 mg，0.025 mmol）在氮?dú)獗Ｗo(hù)下于5 mL脫氣的四氫呋喃中攪拌30分鐘。之后，通過轉(zhuǎn)移針在室溫下將該催化劑溶液逐滴加入主反應(yīng)燒瓶中。滴加完畢后，將反應(yīng)體系加熱至內(nèi)溫110℃，維持反應(yīng)8小時(shí)。反應(yīng)完成后，冷卻至50℃，過濾除去沉淀的固體。濾液經(jīng)減壓濃縮后，用pH3的稀鹽酸進(jìn)行萃取。分離水相后，用氫氧化鈉溶液調(diào)節(jié)至pH10，析出白色固體，過濾并減壓干燥，得到N-(4-三氟甲基苯基)哌嗪22.1 g（96 mmol，收率96%）。產(chǎn)物純度通過定量質(zhì)子NMR測定，確認(rèn)>99%。
參考文獻(xiàn)：
[1] Patent: US2005/250791, 2005, A1. Location in patent: Page/Page column 4
[2] Patent: KR101589584, 2016, B1. Location in patent: Paragraph 0098-0102
[3] Patent: US2005/250791, 2005, A1. Location in patent: Page/Page column 4
[4] Patent: US2005/250791, 2005, A1. Location in patent: Page/Page column 4
[5] Patent: US2005/250791, 2005, A1. Location in patent: Page/Page column 4
知名試劑公司產(chǎn)品信息
N-(alpha,alpha,alpha-Trifluoro-p-tolyl)piperazine, 98%(30459-17-7)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | 36712 | N-(a，a，a-三氟對(duì)甲苯)哌嗪(98%) N-(alpha,alpha,alpha-Trifluoro-p-tolyl)piperazine, 98%, Thermo Scientific Chemicals | 30459-17-7 | 1g | 873元 |
| 2025/05/22 | 36712 | N-(a，a，a-三氟對(duì)甲苯)哌嗪(98%) N-(alpha,alpha,alpha-Trifluoro-p-tolyl)piperazine, 98%, Thermo Scientific Chemicals | 30459-17-7 | 5g | 3652元 |
| 2025/05/22 | T2741 | 1-(4-三氟甲苯基)哌嗪 1-(4-Trifluoromethylphenyl)piperazine | 30459-17-7 | 5g | 580元 |