29270-56-2

基本信息
4-硝基-7-氯-2,1,3-苯并堊二唑
4-氟-7-硝基-2,1,3-苯并氧雜惡二唑
4-FLUORO-7-NITROBENZ-2-OXA-1,3-DIAZOLE
4-FLUORO-7-NITROBENZOFURAZAN
4-FLUORO-7-NITROBENZOFUROZAN
7-FLUORO-4-NITROBENZO-2-OXA-1,3-DIAZOLE
NBD-F
NBD FLUORIDE
NITROBENZOFURAZAN, 4-FLUORO-7-
4-FLUORO-7-NITROBENZOFURAZAN, FOR FLUORE SCENCE
NBD-F (=4-FLUORO-7-NITRO-2,1,3-BENZOXADIAZOLE)
4-Fluoro-7-nitrobenzofurazane
2,1,3-BENZOXADIAZOLE, 4-FLUORO-7-NITRO-
NBD-F (=4-Fluoro-7-nitro-2,1,3-benzoxadiazole) [for HPLC Labeling]
7-Fluoro-4-nitro-2,1,3-benzoxadiazole
7-Nitro-4-fluoro-2,1,3-benzoxadiazole
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表

29270-55-1

29270-56-2
以4-氟-2,1,3-苯并惡二唑?yàn)樵虾铣?-氟-7-硝基-2,1,3-苯并惡二唑的一般步驟:將4-氟-2,1,3-苯并惡二唑(1.00g,7.24mmol)溶于濃H2SO4(8mL)中,冷卻至-10℃。在攪拌下,緩慢滴加硝化混合物(H2SO4:HNO3,3:1,2.40mL)。保持反應(yīng)溫度在-10℃,繼續(xù)攪拌1小時(shí)。通過(guò)TLC和LCMS監(jiān)測(cè)反應(yīng)進(jìn)度。反應(yīng)完成后,將反應(yīng)混合物用H2O(250mL)淬滅,并用EtOAc(2×250mL)萃取。合并有機(jī)層,用無(wú)水Na2SO4干燥,減壓濃縮。粗產(chǎn)物通過(guò)快速柱色譜法(洗脫劑:己烷中0至10% EtOAc梯度)純化,得到4-氟-7-硝基-2,1,3-苯并惡二唑(0.39g,黃色固體),產(chǎn)率30%。1H NMR(400MHz,DMSO-d6)δ 7.70(d,J=8.40Hz,1H),8.77-8.80(m,1H)。
參考文獻(xiàn):
[1] Journal of the American Chemical Society, 2016, vol. 138, # 48, p. 15596 - 15604
[2] Patent: WO2018/122232, 2018, A1. Location in patent: Page/Page column 213
[3] Tetrahedron Letters, 2011, vol. 52, # 20, p. 2533 - 2535
As the percentage of the organic phase changes, the retention time of NBD-F remains relatively stable, while the retention times of the derivatization products changes. The pH of the mobile phase affects the separation of the NBD-F and the derivatization products. NBD-F is a fluorescent derivatization reagent that is originally developed for amino acid analysis, and recently applied to the analysis of other amino acid derivatives such as N-methyl-D-aspartic acid and glutathione. The use of NBD-F appears to have several advantages in that the derivatization procedure is simple and its derivatives are highly stable.
知名試劑公司產(chǎn)品信息
NBD-F, 98%(29270-56-2)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2025/05/22 | 41545 | 4-氟-7-硝基苯并-2-氧雜-1,3-二唑,98% 5MG 4-Fluoro-7-nitrobenzofurazan, 98%, Thermo Scientific Chemicals | 29270-56-2 | 5mg | 1350元 |
2025/05/22 | 41545 | 4-氟-7-硝基苯并-2-氧雜-1,3-二唑,98% 5MG 4-Fluoro-7-nitrobenzofurazan, 98%, Thermo Scientific Chemicals | 29270-56-2 | 25mg | 4314元 |
2025/05/22 | HY-D0785 | 4-氟-7-硝基苯并-2-氧雜-1,3-二唑 NBD-F | 29270-56-2 | 50mg | 600元 |