28697-17-8
28697-17-8 結(jié)構(gòu)式
基本信息
BOC-D-高脯氨酸
BOC-D-哌啶-2-羧酸
(R)-(+)-1-叔丁氧羰基-2-哌啶羧酸
N-Boc-D-哌啶-2-羧酸
(2R)-1-(TERT-BUTOXYCARBONYL)HEXAHYDROPYRIDINE-2-CARBOXYLIC ACID
(2R)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-2-CARBOXYLIC ACID
2(R)-1-(TERT-BUTOXYCARBONYL)PIPERIDINECARBOXYLIC ACID
BOC-D-HOMOPROLINE
BOC-D-HOMOPRO-OH
BOC-D-HOPRO-OH
BOC-D-PIC(2)-OH
BOC-D-(+)-PIPECOLIC ACID
BOC-D-PIPECOLIC ACID
BOC-D-PIPECOLINIC ACID
BOC-D-PIPERIDINE-2-CARBOXYLIC ACID
BOC-D-PIP-OH
BOC-(R)-(+)-PIPERIDINE-2-CARBOXYLIC ACID
BOC-R-PIP-OH
(D)-N-BOC-PIPECOLIC ACID
(D)-N-(T-BUTOXYCARBONYL)PIPECOLIC ACID
(D)-N-(TERT-BUTOXYCARBONYL)PIPECOLIC ACID
N-ALPHA-T-BOC-D-PIPECOLIC ACID
N-ALPHA-T-BUTOXYCARBONYL-D-HOMOPROLINE
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
24424-99-5
1723-00-8
28697-17-8
以二碳酸二叔丁酯和D-(+)-2-哌啶酸為原料合成(R)-1-(叔丁氧羰基)哌啶-2-羧酸的一般步驟如下：向1000 mL圓底燒瓶中加入D-(+)-2-哌啶酸（8.0 g，0.062 mol）、二碳酸二叔丁酯（14.8 g，0.068 mol）、碳酸氫鈉（26.04 g，0.310 mol）和甲醇（400 mL）。將混合物在室溫下攪拌反應(yīng)24小時(shí)。反應(yīng)完成后，通過(guò)減壓蒸餾除去甲醇。殘余物用水溶解，隨后用乙醚洗滌三次。用飽和硫酸氫鉀溶液調(diào)節(jié)水相pH至2，然后用二氯甲烷萃取三次。合并有機(jī)相，用飽和食鹽水洗滌三次，經(jīng)無(wú)水硫酸鈉干燥后濃縮。粗產(chǎn)物通過(guò)硅膠柱色譜純化，洗脫劑為石油醚/乙酸乙酯/乙酸混合溶劑，最終得到12.48 g白色固體產(chǎn)物，產(chǎn)率為87.8%。產(chǎn)物經(jīng)1H-NMR（400 MHz, DMSO）和EI-MS表征：1H-NMR δ 12.71 (1H, s), 4.61 (1H, d, J = 28.8 Hz), 3.82 (1H, d, J = 12 Hz), 2.93 (1H, m), 2.06 (1H, s), 1.62 (3H, m), 1.39 (11H, m); EI-MS m/z: 229.1 [M]+。
參考文獻(xiàn)：
[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 4, p. 591 - 601
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 9, p. 1550 - 1557
[3] ChemMedChem, 2013, vol. 8, # 4, p. 577 - 581
[4] Patent: EP2805947, 2014, A1. Location in patent: Paragraph 0074-0075
[5] Patent: US2015/126500, 2015, A1. Location in patent: Paragraph 0127; 0128
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | H51961 | N-Boc-D-哌啶-2-羧酸, 98% N-Boc-D-pipecolinic acid, 98% | 28697-17-8 | 5g | 814元 |
| 2025/05/22 | H51961 | N-Boc-D-哌啶-2-羧酸, 98% N-Boc-D-pipecolinic acid, 98% | 28697-17-8 | 25g | 2209元 |
| 2025/05/22 | 39925 | (R)-(+)-N-Boc-哌啶-2-羧酸 (R)-(+)-N-BOC-2-Piperidinecarboxylic acid, 98%, Thermo Scientific Chemicals | 28697-17-8 | 1g | 576元 |