26944-71-8

基本信息
2-溴-6-肼基吡啶
6-溴-2-肼基吡啶
(6-溴吡啶-2-基)肼
(6-溴-2-吡啶基)肼
2-肼基-6-溴吡啶鹽酸鹽
2-肼基-6-溴吡啶(CAS號:26944-71-8)
2-hydrazine-6-bromopyridine
2-Diazanyl-6-Bromo Pyridine
2-Bromo-6-hydrazinopyridine
(6-bromo-2-pyridyl)hydrazine
2-BROMO-6-HYDRAZINYLPYRIDINE
(6-Bromopyridin-2-yl)hydrazine
Pyridine, 2-bromo-6-hydrazinyl-
2-Bromo-6-hydrazinopyridine,98%
1-(6-bromopyridin-2-yl)hydrazine
物理化學(xué)性質(zhì)
制備方法

626-05-1

26944-71-8
以2,6-二溴吡啶為原料合成2-溴-6-肼基吡啶的一般步驟:將市售的2,6-二溴吡啶(4.12g,16.6mmol)懸浮于乙醇(40mL)中,隨后加入水合肼(10mL,97.6mmol,50-60%水溶液)。將反應(yīng)混合物置于115℃的沙浴中加熱回流18小時。反應(yīng)完成后,減壓蒸餾除去溶劑,所得殘余物通過硅膠柱色譜法純化,洗脫劑為乙酸乙酯/正庚烷(60/40,v/v),得到2-溴-6-肼基吡啶,為灰白色固體(3.05g,收率93%)。1H-NMR(400MHz,CDCl3)δ:7.33(t,1H),6.83(d,1H),6.67(d,1H),6.00(br-s,1H),3.00-3.33(br-s,2H)。
參考文獻(xiàn):
[1] Patent: US2011/256064, 2011, A1. Location in patent: Page/Page column 22
[2] Patent: EP2377860, 2011, A1. Location in patent: Page/Page column 29
[3] Patent: US2011/280808, 2011, A1. Location in patent: Page/Page column 54
[4] Patent: WO2015/110263, 2015, A1. Location in patent: Page/Page column 159
[5] Patent: US2017/2005, 2017, A1. Location in patent: Paragraph 0760; 0761; 0762; 0763