24155-42-8
24155-42-8 結構式
基本信息
1-(2,4-二氯苯基)-2-(1-H-咪唑)乙醇
1-(2,4-二氯苯基)-2-(1H-咪唑基)-乙醇
1-[2-羥基-2-(2,4-二氯苯基)乙基]咪唑
α-(2,4-二氯苯基)-1H-咪唑-1-乙醇
咪唑縮合物
2-(2,4-二氯苯基)-1-氫咪唑-1-乙醇
咪唑乙醇
1-(2,4-二氯苯基)-2-(1-咪唑基)乙醇
1-(2,4-二氯苯基)-1H-咪唑基-1-乙醇
1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol
1-(2,4-DICHLOROPHENYL)-2-IMIDAZOL-1-YL ETHANOL
1H-IMIDAZOLE-1-ETHANOL, ALPHA-(2,4-DICHLOROPHENYL)-
ALPHA-(2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-1-ETHANOL
ALPHA-(2,4-DICHLOROPHENYL)-2-1H-IMIDAZOLE-1-ETHANOL
ALPHA-(2,4-DICHLORO PHENYL)-B-(IMIDAZOLE-YL)ETHANOL
-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
2,4-dichloro-alpha-(1-imidazolylmethyl)-benzylalcoho
alpha-(2,4-dichlorophenyl)-imidazole-1-ethano
n-(beta-(2,4-dichlorophenyl)-beta-hydroxyethyl)imidazole
r14821
t824
1-(2,4-Dichlorphenyl)-2-1-Imidazolyl)-Ethanol
1-(2,4-Dichlorophenyl)-2-((1H)-imidazol-1-yl)-ethane
alpha-(2,4-Dichlorophenyl)-1H-
2-(2,4-dichlorobenzene)-imidazole-1-ethanol
ALPHA- (2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-ETHANOL
IMIDAZOLE ETHANOL
Imidazole-1-ethanol alpha-(2,4-dichlorophenyl)
物理化學性質(zhì)
制備方法
46503-52-0
24155-42-8
以2'-(1H-咪唑-1-基)-2,4-二氯苯乙酮為原料合成alpha-(2,4-二氯苯基)-1H-咪唑-1-乙醇的一般步驟：在配備有攪拌器、溫度計和滴液漏斗的1000 mL三頸燒瓶中，加入102 g 2'-(1H-咪唑-1-基)-2,4-二氯苯乙酮（0.4 mol）和300 mL甲醇。分批加入硼氫化鉀，緩慢加熱至回流。反應完成后，繼續(xù)攪拌1小時，并通過薄層色譜（TLC）監(jiān)測反應進程（展開劑為乙酸乙酯：甲醇=10:1，v/v）。反應結束后，減壓蒸餾回收甲醇。將濃縮液用5%鹽酸溶液調(diào)節(jié)pH至4-5，隨后進行抽濾。濾液用5%碳酸氫鈉溶液調(diào)節(jié)pH至7-8，此時有白色固體析出。抽濾收集固體，用水洗滌，干燥后進行重結晶，得到93.1 g 1-(2,4-二氯苯基)-2-(1H-咪唑-1-基)乙醇，產(chǎn)率為90.5%，熔點為134-135℃。
參考文獻：
[1] Patent: CN102180835, 2016, B. Location in patent: Paragraph 0015; 0016
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1665 - 1674
[3] Polyhedron, 2013, vol. 52, p. 106 - 114
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4288 - 4294
[5] Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 162 - 175