239074-29-4
239074-29-4 結(jié)構(gòu)式
基本信息
反-(4-羥甲基)環(huán)己基氨基甲酸叔丁酯
(反式-4-羥甲基環(huán)己基)氨基甲酸叔丁酯
反式-1-(BOC-氨基)-4-(羥甲基)環(huán)己烷
叔-丁基 N-[反-4-(羥甲基)環(huán)己基]氨基甲酯
反式-1-(BOC-氨基)-4-(羥甲基)環(huán)己烷,97%
trans-4-(Boc-amino)cyclohexanemethanol
trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane,97%
trans-1-(Boc-aMino)-4-(hydroxyMethyl)cyclohexane, 97%
TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
Trans tert-butyl 4-(hydroxyMethyl)cyclohexyl)carbaMate
trans-4-(tert-Butoxycarbonylamino)cyclohexane-1-methanol
tert-butyl N-[trans-4-(hydroxymethyl)cyclohexyl]carbamate
tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)carbamate
tert-Butyl trans-4-(hydroxymethyl)cyclohexylcarbamate FP160825
物理化學(xué)性質(zhì)
制備方法
146307-51-9
239074-29-4
以反式-4-(叔丁氧羰基氨基)環(huán)己烷甲酸甲酯為原料合成反-(4-羥甲基)環(huán)己基氨基甲酸叔丁酯的一般步驟：在冰浴條件下，將LiAlH4（9.0 g，0.236 mol，1.12當(dāng)量）在THF（500 mL）中的懸浮液冷卻至0℃。隨后，緩慢加入反式-4-(叔丁氧羰基氨基)環(huán)己烷甲酸甲酯（54.3 g，0.21 mol，1.0當(dāng)量）的THF（200 mL）溶液，確保反應(yīng)溫度維持在10℃以下。加料完畢后，將反應(yīng)混合物轉(zhuǎn)移至室溫?cái)嚢柽^夜。反應(yīng)完成后，在15℃至25℃下，用十水合硫酸鈉（27 g）小心淬滅反應(yīng)。通過過濾去除不溶物，濃縮濾液，得到反-(4-羥甲基)環(huán)己基氨基甲酸叔丁酯（43 g，收率89%），為白色粉末。MS-ESI：[M + 1]+：229.1。
參考文獻(xiàn)：
[1] Patent: WO2018/67422, 2018, A1. Location in patent: Page/Page column 44; 45
[2] Patent: WO2018/69863, 2018, A1. Location in patent: Page/Page column 121-122
[3] Patent: EP2017261, 2009, A1. Location in patent: Page/Page column 30-31
[4] Patent: US2010/273841, 2010, A1. Location in patent: Page/Page column 22
[5] Patent: WO2011/92293, 2011, A2. Location in patent: Page/Page column 99-100
| 報(bào)價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | H62487 | 反式-1-(Boc-氨基)-4-(羥甲基)環(huán)己烷, 97% trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane, 97% | 239074-29-4 | 1g | 496元 |
| 2025/05/22 | H62487 | 反式-1-(Boc-氨基)-4-(羥甲基)環(huán)己烷, 97% trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane, 97% | 239074-29-4 | 5g | 2102元 |
| 2025/05/22 | H62487 | 反式-1-(Boc-氨基)-4-(羥甲基)環(huán)己烷, 97% trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane, 97% | 239074-29-4 | 25g | 10070元 |