23735-43-5
23735-43-5 結(jié)構(gòu)式
基本信息
(S)對(duì)甲基苯磺酸-2,2-二甲基-1,3-二氧戊環(huán)基-4-甲酯
(S)-(+)-2,2-二甲基-1,3-二氧環(huán)戊基-4-甲醇對(duì)甲基苯磺酸酯
2,2-DIMETHYL-4(S)-4-(P-TOLYLSULFONYL)METHYL-1,3-DIOXALANE
2,3-ISOPROPYLIDENE-SN-GLYCEROL 1-TOSYLATE
L-(+)-1,2-ISOPROPYLIDENEGLYCEROL 3-(P-TOLUENESULFONATE)
L-ALPHA,BETA-ISOPROPYLIDENEGLYCEROL-GAMMA-TOSYLATE
(S)-1,2-O-ISOPROPYLIDENEGLYCEROL-3-TOLUENESULFONATE
(S)-(+)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE
(S)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL-4-METHYLBENZENESULFONATE
(S)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL TOLUENE-4-SULFONATE
(S)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL TOSYLATE
(S)-(+)-2,2-DIMETHYL-1,3-DIOXOLANE-4-YLMETHYL P-TOLUENESULFONATE
(S)-(+)-2,2-DIMETHYL-4-(HYDROXYMETHYL)-1,3-DIOXOLANE-P-TOLUENESULFONATE
(S)-2,2-DIMETHYL-4-(HYDROXYMETHYL)-1,3-DIOXOLANE-P-TOLUENESULFONATE
(S)-(+)-2,2-DIMETHYL-4-(HYDROXYMETHYL)-1,3-DIOXOLANE-P-TOLUENSULFONATE
(S)-3-TOSYLOXY-1,2-PROPANEDIOL ACETONIDE
(S)-O-ISOPROPYLIDENE GLYCEROL TOSYLATE
(S)-2,2-Dimethyl-1,3-dioxolane-4-methanol p-toluenesulfonate
(S)-3-Toxyloxy-1,2-propanediol acetonide
(s)-2,2-dimethyl-1,3-dioxolane-4-methyl p-toluenesulfonate
(S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol 4-toluenesulfo
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
98-59-9
14347-78-5
23735-43-5
以對(duì)甲苯磺酰氯和(R)-(-)-甘油醇縮丙酮為原料，合成(S)-(2,2-二甲基-1,3-二氧戊環(huán)-4-基)甲基4-甲基苯磺酸酯的一般步驟如下：按照制備(R)-(-)-20a的方法，將(R)-(-)-2,2-二甲基-4-(羥甲基)-1,3-二氧戊環(huán)(19b)(2.50g)轉(zhuǎn)化為(S)-(+)-3-甲苯磺酰氧基-1,2-丙二醇丙酮化合物20b(5.23g，收率98%，ee值99.2%)。[α]D20 +4.5(c 1.0, EtOH)(文獻(xiàn)值[α]D25 +4.7(c 1.0, EtOH))。IR、NMR和HRMS光譜數(shù)據(jù)與(R)-(-)-20a對(duì)映體完全一致。
參考文獻(xiàn)：
[1] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 10, p. 1719 - 1723
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 8, p. 3198 - 3213
[3] Tetrahedron, 2013, vol. 69, # 5, p. 1634 - 1648
[4] Journal of the American Chemical Society, 1980, vol. 102, # 20, p. 6304 - 6311
[5] Journal of the Chemical Society, Chemical Communications, 1984, # 6, p. 349 - 350